Els van de Vijver

82 Table 1: General characteristics of the included studies . First author (year of publication) Study objectives Age (years) Patient population Percentage of patients with active disease Main findings related to fatigue Marcus (2009) [6] To evaluate the degree of fatigue and health- related quality-of-life in children with IBD 10-17 52 CD 13 UC 5 IBD-U 157 healthy controls Remission 56% Mild 22% Moderate 17% Severe 5% -adolescents with IBD have significantly more fatigue than healthy controls -PedsQL total fatigue, general fatigue, and sleep/rest fatigue were all impaired in patients with IBD - adolescents with IBD are fatigued even when clinical remission is reached Nicholas (2007) [13] To understand the lived experience and elements of quality-of- life in adolescents and adolescents with IBD 7-19 61 CD 19 UC Not reported - Young patients with IBD commonly feel ‘sick and tired’ and have ‘no energy’ Pirinen (2010) [16] To evaluate the effect of disease severity on (the frequency of) sleep problems and daytime- tiredness among adolescents with IBD 10-18 53 CD 83 UC 24 IBDU 236 healthy controls Not reported - Adolescents with IBD do not report more sleeping problems or overtiredness than their healthy peers -Adolescents with active disease have significantly more trouble sleeping, more daytime sleepiness and are overtired compared to adolescents with mild IBD symptoms - Adolescents with severe IBD symptoms have worse quality of sleep and more sleep disturbances than those with less severe IBD Chapter 5 82