Els van de Vijver

83 Werkstetter et al. (2012) [8] To evaluate whether physical activity is reduced in patients with IBD compared to control subjects 6-20 27 CD 12 UC 39 healthy controls Remission 66% Mild 34% -Patients with IBD show a trend toward less physical activity, especially among girls and those with mild disease activity -There is no relation between inflammatory markers (CRP) and physical activity Rogler (2013) [7] To examine the determinants of health- related quality-of-life in adolescents and adolescents with IBD 11-15 64 CD 46 UC PCDAI> 15 36% PUCAI≥ 10 28% -Patients with IBD (in particular boys) have moderate impairments in physical well-being -Impairment in physical well-being is associated with active inflammation and its symptoms Loonen (2002) [12] To evaluate the impact of IBD on health- related quality of life 8-18 41 CD 40 UC 2 IBD-U Mild 60% Moderate 23% Severe 15% Missing 2% - Adolescents with IBD have impairments in motor functioning (running, walking, playing) and complain more of tiredness, especially those with Crohn’s disease Tojek et al. (2002) [14] To examine family dysfunction, maternal physical symptoms and maternal positive affect as correlates of health status in adolescents with IBD 11-18 36 CD 26 UC Not reported -Family dysfunction is related to an increased frequency of fatigue in adolescents -Maternal positive affect is inversely related to fatigue (not significant) -Fatigue is independent of maternal negative affect Ondersma et al. (1996) [15] To examine how psychological factors relate to disease severity among adolescents with IBD 11-17 34 CD 22 UC Not reported There is a relationship between negative affect and physical symptoms of fatigue CD Crohn’s disease, IBD inflammatory bowel disease, IBD-U IBD-unclassified, PCDAI paediatric Crohn’s disease activity, PedsQL paediatric quality of life, PUCAI paediatric ulcerative colitis activity index, UC ulcerative colitis Systematic review: fatigue 83