Adriëtte Oostvogels

4 109 Maternal lipids and offspring’s lipids & glucose Maternal lipids and offspring’s lipids Table 2 shows the results of the linear regression analyses conducted to examine the association between maternal lipids and offspring’s lipids. The betas are given separately for boys and girls as significant interactions (p<0.05) were found in the associations between maternal TC and offspring’s TC and LDL, maternal ApoA1 and offspring’s TG, maternal ApoB and offspring’s TC and LDL, and maternal TG and offspring’s HDL. In model 1, positive associations were found between maternal TC and offspring’s TC (boys and girls), offspring’s LDL (boys and girls) and offspring’s TG (only girls). Furthermore, maternal ApoA1 was positively associated with offspring’s TC (only girls), offspring’s HDL (only boys) and offspring’s TG (only girls). Other positive associations were found between maternal ApoB and offspring’s TC (boys and girls), offspring’s LDL (boys and girls) and offspring’s TG (boys and girls). Finally, maternal TG were also positively associated with offspring’s TC (only girls), offspring’s LDL (only girls) and offspring’s TG (boys and girls). Adjusting for the covariates in model 2 minimally altered the results of model 1, with the exception of the association between maternal ApoB and offspring’s TG, which became non- significant. Maternal lipids and offspring’s glycaemic control Table 3 presents the associations between maternal lipids and offspring’s glucose, C-peptide and HOMA2-IR. Table 3 does not distinguish between boys and girls, as no significant interactions (p>0.05) were found in the associations. No significant associations were found between maternal lipids and offspring’s glycaemic control parameters. Mediating role of offspring’s fat percentage Adjusting for offspring’s fat percentage (model 3) minimally altered the effect size of the associations between maternal lipids and offspring’s lipid levels and glycaemic control parameters. Moreover, there was no evidence for a mediating role of offspring’s fat percentage in these associations when the indirect effect was tested according to the approach of Preacher and Hayes. In addition, in this analysis no association was found between maternal lipids and offspring’s fat percentage (data not shown).