Adriëtte Oostvogels

112 Chapter 4 Offspring’s glycaemic control Glucose (mmol/l) C-peptide -1 (nmol/L) HOMA2-IR -1 Maternal lipids β 95%CI β 95%CI β 95%CI TC (mmol/l) (n=1104 d /n=831 e ) M1 a -0.008 -0.043-0.027 0.011 -0.041-0.063 0.005 -0.021-0.032 M2 b -0.005 -0.041-0.030 0.018 -0.035-0.071 0.008 -0.019-0.035 M3 c -0.007 -0.042-0.029 0.023 -0.027-0.074 0.011 -0.015-0.037 ApoA1 (g/l) (n=1065 d /n=811 e ) M1 -0.028 -0.160-0.103 -0.103 -0.299-0.092 -0.048 -0.147-0.051 M2 -0.018 -0.153-0.117 -0.140 -0.340-0.060 -0.069 -0.171-0.032 M3 -0.021 -0.156-0.114 -0.126 -0.318-0.066 -0.062 -0.159-0.035 ApoB (g/l) (n=1074 d /n=818 e ) M1 -0.020 -0.193-0.153 0.075 -0.182-0.332 0.035 -0.096-0.165 M2 -0.028 -0.206-0.151 0.164 -0.102 -0.429 0.082 -0.052-0.217 M3 -0.034 -0.212-0.145 0.188 -0.065-0.442 0.095 -0.034-0.225 TG (mmol/l) (n=1104 d /n=831 e ) M1 0.018 -0.038-0.073 <0.000 -0.086-0.087 0.003 -0.041-0.047 M2 0.011 -0.047-0.069 0.030 -0.059-0.119 0.018 -0.028-0.063 M3 0.013 -0.045-0.070 0.013 -0.073-0.099 0.009 -0.034-0.053 FFA (mmol/l) (n=1017 d /n=775 e ) M1 0.047 -0.135-0.229 -0.094 -0.368-0.181 -0.039 -0.179-0.100 M2 -0.011 -0.200-0.177 -0.026 -0.310-0.259 0.003 -0.141-0.147 M3 -0.019 -0.207-0.170 0.029 -0.244-0.302 0.030 -0.108-0.168 Table 3. Linear regression model of the association between maternal early pregnancy lipids and offspring’s glycaemic control at age 5-6 years. HOMA2-IR, insulin resistance index; TC, total cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; TG, triglycerides; FFA, free fatty acids. a) M1: adjusted for gestational age at blood sampling and child’s sex and age. b) M2: adjusted for model 1 + maternal age, parity, ethnicity, smoking, hypertension, alcohol intake, years of education, pre pregnancy BMI, duration of breastfeeding, screen time hours, saturated fat intake and dietary fibre intake. c) M3: adjusted for model 2+ fat percentage. d) sample size for analyses with offspring’s glucose. e) sample size for analyses with offspring’s C-peptide and HOMA2-IR.