Adriëtte Oostvogels

FHD (reference) FHD (comparison) BMI (kg/m 2 ) N=2020 WHtR*100 N=2017 Fat% N=1992 Glucose (mmol/L) N=1328 C-peptide (nmol/L) N=981 No FHD (n=1574) Maternal FHD only (n=210) Model 1 0.06 (-0.12;0.25) -0.09 (-0.47;0.29) 0.72 (-0.10;1.55) 0.01 (-0.07;0.09) 0.00 (-0.01;0.01) Model 2 0.05 (-0.04;0.14) -0.10 (-0.29;0.10) 0.63 (-0.17;1.44) 0.01 (-0.07;0.09) 0.00 (-0.01;0.01) Model 3 -0.01 (-0.18;0.16) -0.18 (-0.55;0.20) 0.38 (-0.42;1.18) 0.01 (-0.07;0.10) 0.00 (-0.01;0.01) Paternal FHD only (n=186) Model 1 0.05 (-0.14;0.25) 0.19 (-0.21;0.59) -0.10 (-0.98;0.77) 0.05 (-0.04;0.13) 0.00 (-0.01;0.01) Model 2 0.10 (-0.06;0.25) 0.22 (-0.17;0.62) 0.00 (-0.83;0.83) 0.04 (-0.05;0.13) 0.00 (-0.01;0.01) Model 3 0.00 (-0.18;0.18) 0.13 (-0.27;0.53) 0.27 (-1.12;0.58) 0.04 (-0.05;0.13) 0.00 (-0.01;0.01) Maternal + Paternal FHD (n=63) Model 1 0.10 (-0.21;0.42) -0.28 (-0.94;0.39) 0.20 (-1.23;1.64) 0.08 (-0.07;0.24) 0.03 (0.01;0.05) Model 2 0.09 (-0.22;0.39) -0.28 (-0.93;0.37) 0.01 (-1.41;1.42) 0.07 (-0.08;0.23) 0.03 (0.01;0.05) Model 3 -0.05 (-0.35;0.25) -0.41 (-1.07;0.24) -0.35 (-1.75;1.05) 0.06 (-0.10;0.22) 0.02 (0.01;0.04) Maternal FHD only Paternal FHD only Model 1 -0.01 (-0.26;0.24) 0.28 (-0.24;0.80) -0.83 (-1.96;0.30) 0.03 (-0.08;0.15) 0.00 (-0.01;0.02) Model 2 -0.05 (-0.20;0.28) 0.32 (-0.20;0.84) -0.63 (-1.74;0.48) 0.03 (-0.08;0.15) 0.00 (-0.01;0.02) Model 3 0.01 (-0.22;0.25) 0.31 (-0.21;0.83) -0.65 (-1.75;0.45) 0.03 (-0.09;0.14) 0.00 (-0.01;0.02) Maternal + Paternal FHD Model 1 0.04 (-0.32;0.39) -0.19 (-0.93;0.55) -0.52 (-2.13;1.08) 0.07 (-0.10;0.24) 0.05 (0.02;0.08) Model 2 0.03 (-0.31;0.37) -0.18 (-0.92;0.56) -0.63 (-2.20;0.95) 0.07 (-0.11;0.24) 0.05 (0.02;0.08) Model 3 -0.04 (-0.37;0.29) -0.24 (-0.97- 0.50) -0.73 (-2.29;0.83) 0.04 (-0.13;0.22) 0.04 (0.01;0.08) Paternal FHD only Maternal + Paternal FHD Model 1 0.05 (-0.31;0.41) -0.47 (-1.22;0.28) 0.30 (-1.33;1.95) 0.04 (-0.14;0.21) 0.04 (0.01;0.08) Model 2 -0.01 (-0.36;0.34) -0.50 (-1.25;0.24) 0.01 (-1.60;1.61) 0.04 (-0.14;0.21) 0.04 (0.01;0.08) Model 3 -0.05 (-0.39;0.28) -0.55 (-1.29;0.20) -0.08 (-1.66;1.51) 0.01 (-0.16;0.19) 0.04 (0.01;0.08) Supplementary Table 3. Offspring’s metabolic outcomes (95% CI) per family history of diabetes (FHD) category (only for the Dutch group; N=2033) within the ABCD-study Model 1: adjusted for sex of the child and age at the measurements Model 2: adjusted for model 1 + maternal age, maternal education, maternal ethnicity, standardized birth weight Model 3: adjusted for model 2 + maternal BMI and paternal BMI at children’s age 5 years, child’s energy intake, screen time and fat% (only for glucose and C-peptide) at age 5-6 years * p<0.05 significantly different from the reference category 142 Chapter 5