Adriëtte Oostvogels

5 FHD (reference) FHD (comparison) C-peptide No FHD (n=350) Maternal FHD only (n=65) Model 1 0.00 (-0.02;0.02) Model 2 0.00 (-0.03;0.02) Model 3 -0.01 (-0.04;0.03) Paternal FHD only (n=57) Model 1 -0.02 (-0.03;0.01) Model 2 -0.02 (-0.04;0.01) Model 3 -0.03 (-0.06;0.01) Maternal + Paternal FHD (n=36) Model 1 0.02 (0.00;0.05)* Model 2 0.03 (-0.01;0.07) Model 3 0.05 (-0.00;0.11) Maternal FHD only Paternal FHD only Model 1 -0.01 (-0.04;0.01) Model 2 -0.01 (-0.04;0.02) Model 3 -0.02 (-0.06-0.02) Maternal + Paternal FHD Model 1 0.02 (-0.01;0.06) Model 2 0.03 (-0.01;0.08) Model 3 0.05 (-0.00;0.13) Paternal FHD only Maternal + Paternal FHD Model 1 0.04 (0.01;0.08)* Model 2 0.04 (0.01;0.09)* Model 3 0.08 (0.02;0.15)* Supplementary Table 4. C-peptide levels (95% CI) per family history of diabetes (FHD) category (only for the group with C-peptide above the detection limit; N=508) within the ABCD-study Model 1: adjusted for sex of the child and age at the measurements Model 2: adjusted for model 1 + maternal age, maternal education, maternal ethnicity, standardized birth weight Model 3: adjusted for model 2 + maternal BMI and paternal BMI at children’s age 5 years, child’s energy intake, screen time and fat% (only for glucose and C-peptide at age 5-6 years * p<0.05 significantly different from the reference category 143 Family history of diabetes and childhood outcomes