Adriëtte Oostvogels

Chapter Title Determinants Outcomes Mediation/Moderation Part 1 Consequences of maternal prepregnancy BMI on metabolic markers in mothers and cardiometabolic profile in childhood 2 Prepregnancy weight status, early pregnancy lipid profile and blood pressure course during pregnancy: the ABCD study Maternal prepregnancy weight status: • Overweight yes/no Maternal early pregnancy lipid profile: • Total cholesterol • Apolipoprotein A1 • Apolipoprotein B • Triglycerides • Free Fatty Acids Systolic and diastolic blood pressure course during pregnancy Mediation and moderation of maternal early pregnancy lipid profile in the association between prepregnancy weight status and blood pressure course during pregnancy 3 Maternal prepregnancy BMI and lipid profile during early pregnancy are independently associated with offspring’s body composition at age 5–6 years: the ABCD study Maternal prepregnancy weight status: • Continuous pBMI Maternal early pregnancy lipid profile: • Total cholesterol • Apolipoprotein A1 • Apolipoprotein B • Triglycerides • Free Fatty Acids Offspring’s body composition in early childhood: • Body mass index (BMI) • Waist-height ratio • Fat percentage • Overweight yes/no Mediation of maternal early pregnancy lipid profile in the association between maternal prepregnancy BMI and offspring’s body composition 4 Maternal early pregnancy lipid profile and offspring’s lipids and glycaemic control at age 5-6 years: the ABCD study Maternal early pregnancy lipid profile: • Total cholesterol • Apolipoprotein A1 • Apolipoprotein B • Triglycerides • Free Fatty Acids Offspring’s lipids & glycaemic control in early childhood: • Total cholesterol • HDL-Cholesterol • LDL-Cholesterol • Triglycerides • Free fatty acids • Glucose • C-peptide • HOMA-IR Mediation of offspring’s fat percentage in the association between maternal early pregnancy lipid profile in the association and offspring’s lipid profile and glycaemic control Moderation boy/girls Table 1. Outline 18 Chapter 1