Adriëtte Oostvogels

1 Chapter Title Determinants Outcomes Mediation/Moderation 5 Maternal and paternal family history of diabetes in second-degree relatives and metabolic outcomes at age 5-6 years: the ABCD-study Second degree family history of diabetes (FHD): • No FHD • Maternal FHD • Paternal FHD • Maternal + Paternal FHD Early childhood metabolic outcomes: • BMI • Waist-height ratio • Fat percentage • Glucose • C-peptide - Part 2 Consequences of maternal prepregnancy BMI on postnatal growth and cardiometabolic profile in childhood 6 Does maternal prepregnancy overweight or obesity influence offspring’s growth patterns from birth up to 7 years? The ABCD-study. Maternal prepregnancy weight status: • Overweight yes/no Postnatal growth 0-7 years: • SD-scores Weight • SD-scores Height • SD-scores BMI Moderation boys/girls 7 Maternal prepregnancy BMI, offspring’s early postnatal growth and metabolic profile at age 5-6 years: the ABCD-study Maternal prepregnancy weight status: • Continuous pBMI Offspring’s postnatal growth: • Weight gain 0-3 months • Weight-for-height gain 0-3 months Offspring’s early childhood metabolic profile: • Waist-height ratio • SBP • DBP • Glucose • HDL-cholesterol Sum-score of metabolic traits Mediation and moderation of early postnatal growth in the association between prepregnancy BMI and offspring’s metabolic profile 8 Growth patterns from birth to normal weight or overweight at age 5-6 years of children with different socioeconomic and ethnic backgrounds: the ABCD-study. Childhood overweight yes/no Maternal ethnicity Maternal socioeconomic status Offspring’s postnatal growth to overweight at age 5-6 years Moderation boys/girls Table 1 - Continued 19 General introduction