Adriëtte Oostvogels

2 41 pBMI, lipids and BP during pregnancy Normal weight (n=2500) Overweight (n=600) %/mean (SD) %/mean (SD) p-value Age (years) 31.1 (4.6) 31.1 (4.9) P=0.693 Body mass index (kg/m 2 ) 21.4 (4.6) 28.2 (3.4) P<0.001 Education (years) 9.8 (3.5) 8.0 (4.1) P<0.001 Ethnicity P<0.001 - Dutch 65.3 50.3 - Surinamese-Hindu 1.5 1.3 - Black Caribbean 3.1 9.2 - Turkish 3.6 5.7 - Moroccan 3.7 13.0 - Ghanaian 0.4 3.5 - Other 22.4 17.0 % Nulliparous 60.6 47.5 P<0.001 % Smoking during pregnancy 9.6 8.3 P=0.390 % Alcohol consumption during pregnancy 29.0 15.3 P<0.001 Gestational age at lipid measurement (days) 92 (17) 93 (17) P=0.163 Total cholesterol (mmol/L)* 5.38 (0.98) 5.53 (1.01) P=0.001 Apolipoprotein A1 (g/L)* 0.017 (0.002) 0.016 (0.002) P=0.069 Apolipoprotein B (g/L)* 0.008 (0.002) 0.009 (0.002) P<0.001 Triglycerides (mmol/L)* 1.53 (0.59) 1.72 (0.64) P<0.001 Free fatty acids (mmol/L)* 0.31 (0.16) 0.37 (0.20) P<0.001 % Males 49.2 48.8 P=0.892 Gestational age at birth (days) 279 (13) 279 (15) P=0.390 % Preterm 4.6 6.0 P=0.169 Table 1. Characteristics of the study population. * lipids were interpolated to 10 weeks of gestation Table 2. Tertiles of the investigated lipids. a n Lowest tertile Middle tertile Highest tertile Median Range Median Range Median Range TC (mmol/L) 3036 4.50 0.48-4.92 5.33 4.92-5.76 6.34 5.76-11.9 ApoA1 (g/L) 2177 1.43 0.95-1.54 1.64 1.54-1.74 1.88 1.74-2.87 ApoB (g/L) 2193 0.63 0.14-0.72 0.81 0.72-0.89 1.01 0.89-1.96 TG (mmol/L) 3035 1.04 0.28-1.25 1.47 1.25-1.72 2.08 1.72-5.77 FFA (mmol/L) 2079 0.18 0.06-0.23 0.28 0.23-0.35 0.47 0.35-1.27 TC = total cholesterol; ApoA1 = Apolipoprotein A1; ApoB = Apolipoprotein B; TG = triglycerides ; FFA= Free Fatty Acids a) lipids were determined in non-fasting blood samples drawn at a median of 13 (IQR=12-14 ) weeks of gestation.