Adriëtte Oostvogels

Mean difference in average systolic blood pressure (mmHg) pBMI Lipids a Normal weight Overweight Lowest tertile Middle tertile Highest tertile Model 1 Ref 4.3 (3.6-5.1) - - - Model 2 Ref 5.3 (4.6-6.0) - - - Model 3 + TC Ref 5.2 (4.5-5.9) Ref 1.2 (0.5-1.9) 1.9 (1.2-2.6) + ApoA1 Ref 5.5 (4.7-6.4) Ref 0.8 (-0.0-1.6) 1.6 (0.8-2.4) + ApoB Ref 5.2 (4.3-6.0) Ref 1.1 (0.3-1.9) 2.2 (1.4-3.0) + TG Ref 5.2 (4.4-5.9) Ref 0.6 (-0.1-1.2) 1.7 (1.0-2.4) + FFA Ref 5.3 (4.4-6.2) Ref 1.0 (0.2-1.8) 1.3 (0.5-2.2) Table 3. Association between prepregnancy BMI (pBMI) and systolic blood pressure during pregnancy, with maternal lipids Model 1 – crude model; model 2 –adjusted for: maternal age, education, ethnicity, parity, smoking and alcohol use during pregnancy and sex of the foetus; model 3 –adjusted for model 2 + individual lipids separately. TC = total cholesterol (mmol/L); ApoA1 = Apolipoprotein A1 (mg/dL); ApoB = Apolipoprotein B (mg/dL); TG = triglycerides (mmol/L); FFA = Free Fatty Acids (mmol/L) a) lipids were determined in non-fasting blood samples drawn at a median of 13 (IQR=12-14 ) weeks of gestation. 44 Chapter 2 Mean difference in average diastolic blood pressure (mmHg) pBMI Lipids a Normal weight Overweight Lowest tertile Middle tertile Highest tertile Model 1 Ref 3.3 (2.8-3.9) - - - Model 2 Ref 3.9 (3.3-4.5) - - - Model 3 + TC Ref 3.9 (3.3-4.5) Ref 0.3 (-0.2-0.8) 1.1 (0.6-1.6) + ApoA1 Ref 4.1 (3.4-4.7) Ref * * + ApoB Ref 3.9 (3.2-4.6) Ref 0.52 (-0.09-1.14) 1.1 (0.4-1.7) + TG Ref 3.8 (3.3-4.4) Ref * * + FFA Ref 4.0 (3.3-4.6) Ref * 1.0 (0.3-1.6) Table 4. Association between prepregnancy BMI (pBMI) and diastolic blood pressure during pregnancy, with maternal lipids Model 1 – crude model; model 2 –adjusted for: maternal age, education, ethnicity, parity, smoking and alcohol use during pregnancy and sex of the foetus; model 3 – adjusted for model 2 + individual lipids separately. TC = total cholesterol (mmol/L); ApoA1 = Apolipoprotein A1 (mg/dL); ApoB = Apolipoprotein B (mg/dL); TG = triglycerides (mmol/L); FFA = Free Fatty Acids (mmol/L) a) lipids were determined in non-fasting blood samples drawn at a median of 13 (IQR=12-14 ) weeks of gestation. * Significant interactions between tertiles of lipids and time period; blood pressure course for these tertiles are described in detail in the text