Adriëtte Oostvogels

Mean difference in average diastolic blood pressure (mmHg) pBMI Lipids a Normal weight Overweight Lowest tertile Middle tertile Highest tertile Model 1 Ref 2.0 (1.5-2.6) - - - Model 2 Ref 2.7 (2.1-3.3) - - - Model 3 + TC Ref 2.7 (2.1-3.3) Ref 0.0 (-0.5-0.5) 0.6 (0.1-1.1) + ApoA1 Ref 2.6 (1.9-3.2) Ref -0.3 (-0.9-0.3) 0.3 (-0.3-0.9) + ApoB Ref 2.5 (1.8-3.2) Ref 0.2 (-0.4-0.8) 0.7 (0.1-1.3) + TG Ref 2.7 (2.1-3.2) Ref * 0.8 (0.2-1.3) + FFA Ref 2.5 (1.9-3.2) Ref 0.4 (-0.2-1.0) 0.7 (0.1-1.3) Table 4. Association between prepregnancy body mass index (pBMI) and diastolic blood pressure course during pregnancy, with maternal lipids Model 1 – crude model; model 2 –adjusted for: maternal age, education, ethnicity, parity, smoking and alcohol use during pregnancy and sex of the foetus; model 3 – adjusted for model 2 + individual lipids separately. TC = total cholesterol (mmol/L); ApoA1 = Apolipoprotein A1 (mg/dL); ApoB = Apolipoprotein B (mg/dL); TG = triglycerides (mmol/L); FFA = Free Fatty Acids (mmol/L) # lipids were determined in non-fasting blood samples drawn at a median of 13 (IQR=12-14 ) weeks of gestation. * Significant interactions between tertiles of lipids and time period; blood pressure course for these tertiles are described in detail in the text 60 Chapter 2