Enrico Martin

119 Diagnostic accuracy of non-invasive tests Table 1 Study characteristics of included studies. Author, year Study period Mean age (range) Np Nl NF1 Tumor type Non-invasive diagnostics MRI PET-CT Biomarkers MPNST NF S NA Conventional Functional Features TTS Ahlawat 2018 2010-2016 40 (8-68) 42 48 50% 15 11 11 11 T1/T2 DWI/ADC Ahlawat 2019 2010-2017 30 (8-53) 21 55 100% 19 NA NA 36 T1/T2 DWI/ADC SUVmax, size 60 Azizi 2018 2003-2014 14 (3-23) 41 114 100% 16 NA NA 98 SUVmax, T/L 60 Bensaid 2007 2000-2006 31 (7-77) 38 49 100% 6 20 1 22 T/L 60 Benz 2010 2005-2008 46 (21-82) 34 40 41% 17 9 14 0 SUVmax, size 60 Bredella 2007 2000-2006 37 (17-73) 45 50 100% 16 8 NA 26 SUVmax, SUVmean, qual 60 Broski 2016 2002-2014 38 (16-79) 38 43 61% 20 17 6 0 T1/T2 SUVmax, T/L, MTV, TLG, heterogeneity 60 Cardona 2003 NA 45 (18-81) 13 25 38% 13 4 2 6 SUVmean, qual 60 Chhabra 2011 1996-2010 50 (15-92) 56 56 21% 21 24 11 0 T1/T2 Chirindel 2015 2003-2013 36 (8-77) 41 93 100% 24 NA NA 69 60, 240 Combemale 2014 2000-2012 31 (2-77) 113 145 100% 40 55 NA 50 SUVmax, T/L 60 Cook 2017 NA 35 (9-86) 54 54 100% 24 NA NA 30 SUVmax, SUVmean, SUVpeak, GLCM, NGTDM, delayed 90, 240 Demehri 2014 2008-2013 38 (18-54) 29 31 45% 9 6 14 2 T1/T2 DWI/ADC, DCE Derlin 2013 2006-2011 30 (2-63) 31 99 100% 9 NA NA 90 T1/T2 SUVmax, SUVmean, HIsuv 60 Fayad 2014 2009-2012 42 (11-78) 20 24 50% 4 3 6 11 T1/T2 MRS NA Ferner 2000 1996-1998 24 (12-62) 18 23 100% 7 5 NA 11 SUVmean 60 Ferner 2008 1996-2005 31 (5-71) 105 116 100% 29 28 NA 59 SUVmax 60 Furniss 2007 1995-2004 43 (3-87) 30 205 54% 32 100 73 0 NA NA Hummel 2010 NA 21 (5-50) 32 22 100% 5 NA NA 17 ADM, HGF Johansson 2014 NA 36 (12-69) 124 NA 63% NA NA NA NA sAXL Karabatsou 2009 NA 38 (19-63) 9 9 100% 5 4 0 0 SUVmax 60 Karsy 2016 2007-2015 41 ( NA ) 127 127 46% 24 82 17 4 T1/T2 Lerman 2019 2005-2015 35 (15-73) 107 408 100% 39 67 NA 302 SUVmax, T/L, HIsuv, TLG, TMTV 60 Li 2008 NA 47 (20-82) 26 26 NA 9 1 16 0 T1/T2 Matsumine 2008 NA 43 (14-80) 37 37 100% 19 18 0 0 T1/T2 6