Enrico Martin

120 Chapter 6 Table 1 Continued. Author, year Study period Mean age (range) Np Nl NF1 Tumor type Non-invasive diagnostics MRI PET-CT Biomarkers MPNST NF S NA Conventional Functional Features TTS Matsumoto 2015 NA 43 (2-71) 23 23 NA 8 0 15 0 T1/T2 Mautner 2007 NA 25.5 (8-47) 4 4 100% 1 3 0 0 SUVmean NA Meany 2013 NA 18 (10-45) 14 60 100% 2 8 NA 50 SUVmax 60 Moharir 2010 2006-2008 9 (2-14) 11 16 100% 2 NA NA 14 SUVmax 45 Nose 2013 2006-2011 52 (15-88) NA 22 NA 10 2 10 0 SUVmax 60 Park 2013 NA 33 (14-63) 104 NA 100% 30 NA NA 39 IGFBP1, RANTES Razek 2018 NA 34 (9-64) 34 34 100% 11 6 17 0 T1/T2 DWI/ADC Reinert 2018 2012-2018 20 (2-44) 28 83 100% 8 NA NA 75 T1/T2 DWI/ADC SUVmax, T/L, SUVmean 60 Salamon 2013 2006-2011 33 (2-69) 50 159 100% 19 NA NA 140 SUVmax, SUVmean, HIsuv, size, heterogeneity 60 Salamon 2014 2006-2011 33 (2-69) 49 147 100% 18 NA NA 129 SUVmax, T/L, SUVmean, TTF, TTM 60 Salamon 2015 2006-2014 37 (17-69) 36 NA 100% 19 NA NA NA SUVmax, T/L, SUVmean, WB-TLG, WB-MTV, size 60 Schwabe 2019 2007-2016 30 (9-62) 41 70 100% 36 NA NA 34 T1/T2 SUVmax, T/L, SUVpeak 60 Tsai 2012 2000-2011 15 (1-20) 18 26 100% 10 16 0 0 SUVmax 60 Van der Gucht 2016 2006-2012 33 ( NA ) 49 149 100% 16 24 NA 109 SUVmax, T/L, HIsuv, TLG, TMTV 60 Warbey 2009 2004-2008 31 (9-86) 62 85 100% 21 18 NA 46 SUVmax, delayed 90, 240 Wasa 2010 1990-2007 42 (16-83) 61 61 56% 41 20 0 0 T1/T2 Well 2018 2014-2017 34 (17-54) 26 67 100% 12 30 NA 25 T1/T2 DWI/ADC Yu 2016 2011-2015 53 (23-78) 34 34 12% 6 26 2 0 T1/T2 ADC: apparent diffusion coefficient, ADM: adrenomedullin, BPNST: benign peripheral nerve sheath tumor, DCE: dynamic contrast enhancement, DWI: diffusion-weighted imaging, HGF: hepatocyte growth factor, HIsuv: SUV-based heterogeneity index obtained by dividing intratumoral SUVmax by SUVmean of that lesion, IGFBP1: insulin-like growth factor binding protein 1, MPNST: malignant peripheral nerve sheath tumor, MRI: magnetic resonance imaging, MRS: magnetic resonance spectroscopy, MTV: metabolic tumor volume, NA: not available, NF: neurofibroma, Nl: number of lesions, Np: number of patients, PET-CT: positron emission tomography – computed tomography, qual: qualitative PET-CT assessment, RANTES: regulated upon activation normal T-cell expressed and secreted, S: schwannoma, sAXL: soluble fraction from the extracellular domain of AXL, SUVmax: maximum standardized uptake volume, SUVmean: mean standardized uptake volume, T/L: tumor-to-liver ratio, TLG: total lesion glycolysis, TMTV: total metabolic tumor volume, TTF: tumor-to-fat ratio, TTM: tumor-to-muscle ratio, TTS: time to scan in minutes, T1: T1-weighted imaging, T2: T2-weighted imaging.