Enrico Martin

124 Chapter 6 Table 2 Pooled diagnostic performance of Bayesian meta-analyses. Characteristic N Median cut-off (range) Pooled accuracies (95% CI) Sensitivity Specificity Positive LR Negative LR Conventional MRI Ill-defined margins 9 NA 0.52 (0.40-0.65) 0.94 (0.88-0.98) 11.03 (3.83-31.62) 0.51 (0.36-0.66) Perilesional edema 5 NA 0.65 (0.38-0.87) 0.95 (0.83-1.00) 3415.18 (3.15-5948.77) 0.38 (0.12-0.69) Cystic changes 7 NA 0.48 (0.23-0.71) 0.86 (0.61-0.98) 5.75 (1.27-23.69) 0.61 (0.34-0.91) Heterogeneity on T1 3 NA 0.85 (0.56-1.00) 0.48 (0.03-0.96) 9.23 (0.81-31.82) 1.60 (0.01-5.42) Heterogeneity on T2 5 NA 0.78 (0.64-0.90) 0.52 (0.23-0.80) 1.94 (0.90-4.82) 0.49 (0.15-1.37) Tumor enhancement 6 NA 0.63 (0.50-0.76) 0.81 (0.60-0.95) 4.81 (1.44-16.60) 0.46 (0.28-0.72) Irregular shape 4 NA 0.33 (0.04-0.73) 0.82 (0.71-0.90) 2.03 (0.18-5.42) 0.81 (0.26-1.22) Intratumoral lobulation 5 NA 0.57 (0.41-0.72) 0.89 (0.83-0.93) 5.38 (2.87-9.31) 0.49 (0.30-0.68) Absence of target sign 7 NA 0.99 (0.94-1.00) 0.33 (0.15-0.54) 1.51 (1.13-2.25) 0.04 (0.00-0.30) Absence of split-fat sign 3 NA 0.76 (0.57-0.91) 0.44 (0.16-0.78) 1.67 (0.82-4.56) 0.68 (0.15-1.94) Tumor size 3 5.0 (4.7-6.25) 0.72 (0.47-0.92) 0.85 (0.69-0.94) 5.63 (2.05-13.65) 0.34 (0.07-0.67) Qualitative assessment 3 NA 0.71 (0.53-0.85) 0.92 (0.81-0.98) 12.44 (2.13-39.05) 0.32 (0.15-0.56) PET-CT SUVmax 13 3.96 (2.35-6.1) 0.94 (0.91-0.97) 0.81 (0.76-0.87) 5.22 (3.74-7.51) 0.07 (0.03-0.12) Tumor-to-liver ratio 7 1.77 (1.38-3.0) 0.93 (0.87-0.97) 0.79 (0.70-0.86) 4.69 (2.89-7.41) 0.09 (0.03-0.18) Qualitative assessment 5 NA 0.94 (0.88-0.98) 0.82 (0.71-0.91) 5.86 (3.00-11.24) 0.07 (0.02-0.16) PET-CT individual patient-level data SUVmax 11 3.0 0.99 (0.94-1.00) 0.61 (0.40-0.80) 2.82 (1.59-5.64) 0.02 (0.00-0.13) SUVmax 11 3.5 0.99 (0.93-1.00) 0.75 (0.56-0.90) 4.66 (2.12-11.39) 0.02 (0.00-0.13) SUVmax 11 4.0 0.97 (0.86-1.00) 0.78 (0.62-0.91) 5.17 (2.44-11.76) 0.04 (0.00-0.21) SUVmax 11 4.5 0.86 (0.63-0.98) 0.88 (0.77-0.97) 9.59 (3.24-30.96) 0.16 (0.01-0.46) CI: credibility interval, LR: likelihood ratio, MRI: magnetic resonance imaging, N: number of studies, NA: not applicable, PET-CT: positron emission tomography – computed tomography, SUVmax: maximum standardized uptake volume.