Enrico Martin

136 Chapter 6 Supplementary File 1 QUADAS-2 tool for methodological assessment Items Sub-category questions Explanation Answers % Rob: patient selection Was a consecutive or random sample of patients enrolled? Consecutive or random sample Patient enrollment unclear or not described Non-random selection of patients + ? - Was a case-control design avoided? Case control design avoided Case controlled study + - Did the study avoid inappropriate exclusions? Exclusion due to lack of data of index test or reference test Exclusion criteria not described Excluding patients who had received radiotherapy, chemotherapy, percutaneous biopsy, were difficult to diagnose or including only patients with histologically confirmed (benign) lesions + ? -