Enrico Martin

148 Chapter 6 Supplementary Table 2 Diagnostic accuracy non-meta-analysis Study N Characteristic Cut-off Accuracies (95% CI) Sensitivity Specificity pLR nLR Qualitative MRI Chhabra 2011 56 Calcification NA 0.13 (0.03-0.40) 0.94 (0.63-0.99) 2.25 (0.10-49.04) 0.93 (0.71-1.21) Broski 2016 38 1 feature NA 0.81 (0.57-0.93) 0.65 (0.41-0.83) 2.30 (1.16-4.57) 0.29 (0.10-0.85) Broski 2016 38 2 features NA 0.75 (0.51-0.90) 0.88 (0.66-0.97) 6.38 (1.68-24.16) 0.28 (0.12-0.67) Broski 2016 38 3 features NA 0.44 (0.24-0.67) 0.97 (0.78-1.00) 15.88 (0.98-257.27) 0.58 (0.37-0.88) Matsumine 2008 37 Depth NA 0.98 (0.80-1.00) 0.13 (0.04-0.35) 1.12 (0.93-1.36) 0.19 (0.01-3.71) Wasa 2010 61 0.89 (0.77-0.96) 0.21 (0.09-0.43) 1.14 (0.89-1.45) 0.50 (0.15-1.66) Demehri 2014 29 Joint extension NA 0.05 (0.01-0.35) 0.98 (0.82-1.00) 2.3 (0.05-107.97) 0.97 (0.83-1.13) Demehri 2014 29 Eccentricity to nerve NA 0.45 (0.20-0.73) 0.46 (0.27-0.65) 0.83 (0.38- 1.81) 1.21 (0.59-2.47) Li 2008 26 0.95 (0.66-1.00) 0.86 (0.64-0.96) 6.84 (2.15-21.80) 0.06 (0.00-0.87) Demehri 2014 29 Vascular encasement NA 0.15 (0.04-0.46) 0.98 (0.82-1.00) 6.9 (0.31-155.22) 0.87 (0.67-1.14) Demehri 2014 29 Cortical invasion NA 0.15 (0.04-0.46) 0.98 (0.82-1.00 6.9 (0.31-155.22) 0.87 (0.67-1.14) Functional MRI Well 2018 26 ADCdark NA 0.92 (0.65-0.99) 0.98 (0.90-1.00) 50.42 (7.18-354.20) 0.09 (0.01-0.55) Razek 2018 34 ADCmean NA 0.91 (0.62-0.98) 0.91 (0.73-0.98) 10.46 (2.75- 39.82) 0.10 (0.02-0.65) Well 2018 26 0.92 (0.65-0.99) 0.98 (0.90-1.00) 50.42 (7.18-354.20) 0.09 (0.01-0.55) Ahlawat 2019 21 ADCmin <1*10 -3 0.98 (0.80-1.00) 0.93 (0.81-0.98) 14.43 (4.35-47.86) 0.03 (0.00-0.42) Well 2018 26 0.89 (0.62-0.97) 0.94 (0.84-0.98) 14.15 (5.04- 39.77) 0.12 (0.03-0.56) Well 2018 26 dark NA 0.81 (0.54-0.94) 0.99 (0.92-1.00) 90.46 (5.66- 1446.71) 0.19 (0.06-0.59) Well 2018 26 Dmargin NA 0.89 (0.62-0.97) 0.99 (0.92-1.00) 99.08 (6.23- 1575.42) 0.12 (0.03-0.53) Well 2018 26 Dmean NA 0.92 (0.65-0.99) 0.98 (0.90-1.00) 50.42 (7.18- 354.20) 0.09 (0.01-0.55) Well 2018 26 Dmin NA 0.96 (0.72-1.00) 0.96 (0.87-0.99) 21.54 (6.38- 72.70) 0.04 (0.00-0.61) Well 2018 26 fcenter NA 0.96 (0.72-1.00) 0.55 (0.42-0.67) 2.11 (1.55-2.87) 0.07 (0.01-1.08) Well 2018 26 fmargin NA 0.83 (0.55-0.95) 0.75 (0.62-0.84) 3.27 (1.95-5.50) 0.22 (0.06-0.8) Demehri 2014 31 Early arterial enhancement NA 0.50 (0.22-0.79) 0.89 (0.67-0.97) 4.50 (1.03-19.75) 0.56 (0.28-1.15) Ahlawat 2018 42 Target sign on ADC mapping NA 0.97 (0.76-1.00) 0.63 (0.47-0.77) 2.64 (1.68-4.13) 0.05 (0.00-0.77)