Enrico Martin

149 Diagnostic accuracy of non-invasive tests Supplementary Table 2 Continued. Study N Characteristic Cut-off Accuracies (95% CI) Sensitivity Specificity pLR nLR Ahlawat 2018 42 Target sign DWI b-value 50 NA 0.80 (0.55-0.93) 0.39 (0.25-0.56) 1.32 (0.91-1.92) 0.51 (0.17-1.52) Ahlawat 2018 42 Target sign DWI b-value 400 NA 0.93 (0.70-0.99) 0.55 (0.38-0.70) 2.05 (1.38-3.06) 0.12 (0.02-0.83) Ahlawat 2018 42 Target sign DWI b-value 800 NA 0.93 (0.70-0.99) 0.49 (0.33-0.65) 1.81 (1.27-2.59) 0.14 (0.02-0.94) Fayad 2014 16 TMA peak NA 0.90 (0.46-0.99) 0.50 (0.29-0.72) 1.80 (1.03-3.15) 0.20 (0.01-2.89) Fayad 2014 16 TMA fraction >50% 0.90 (0.46-0.99) 0.62 (0.39-0.81) 2.35 (1.20-4.61) 0.16 (0.01-2.31) 18 F-FDG PET Cook 2017 54 SUVpeak NA 0.90 (0.73-0.97) 0.98 (0.86-1.00) 55.80 (3.56- 875.02) 0.10 (0.03-0.33) Schwabe 2019 41 4.5 0.94 (0.78-0.99) 0.69 (0.50-0.83) 2.99 (1.70-5.26) 0.08 (0.02-0.41) Cook 2017 54 SUVpeak 4h NA 0.94 (0.78-0.99) 0.98 (0.86-1.00) 58.28 (3.72-912.70) 0.06 (0.01-0.29) Cook 2017 54 SUVmax 4h NA 0.98 (0.83-1.00) 0.92 (0.77-0.98) 12.15 (3.70-39.94) 0.02 (0.00-0.34) Warbey 2009 62 3.5 0.93 (0.75-0.98) 0.87 (0.77-0.93) 7.13 (3.77-13.47) 0.08 (0.02-0.37) Cardona 2003 13 SUVmean 1.8 0.96 (0.73-1.00) 0.81 (0.54-0.94) 5.01 (1.64-15.35) 0.04 (0.00-0.68) Cook 2017 54 NA 0.90 (0.73-0.97) 0.95 (0.82-0.99) 18.60 (3.88-89.10) 0.11 (0.03-0.34) Cook 2017 54 SUVmean 4h NA 0.96 (0.80-0.99) 0.93 (0.79-0.98) 14.38 (3.76- 54.98) 0.05 (0.01-0.31) Chirindel 2015 41 SULmax 3.2 0.92 (0.74-0.98) 0.87 (0.77-0.93) 7.03 (3.78-13.08) 0.10 (0.03-0.36) Chirindel 2015 41 SULmax 4h 4.1 0.96 (0.80-0.99) 0.88 (0.79-0.94) 8.27 (4.29-15.94) 0.05 (0.01-0.32) Lerman 2019 127 HISUV 1.63 0.84 (0.70-0.92) 0.53 (0.48-0.58) 1.80 (1.51-2.14) 0.30 (0.15-0.62) Salamon 2013 50 1.4 0.98 (0.80-1.00) 0.79 (0.72-0.85) 4.66 (3.36-6.47) 0.03 (0.00-0.49) Salamon 2014 49 Tumor-to-muscle ratio 2.8 0.97 (0.79-1.00) 0.39 (0.31-0.47) 1.59 (1.36-1.86) 0.07 (0.00-1.05) Salamon 2014 49 Tumor-to-fat ratio 7.7 0.97 (0.79-1.00) 0.50 (0.42-0.59) 1.96 (1.63-2.37) 0.05 (0.00-0.81) Broski 2016 38 FDG heterogeneity NA 0.83 (0.63-0.94) 0.44 (0.26-0.63) 1.48 (0.99-2.21) 0.38 (0.13-1.10) Salamon 2013 50 NA 0.98 (0.80-1.00) 0.83 (0.76-0.88) 5.61 (3.89-8.10) 0.03 (0.00-0.47) Chirindel 2015 41 Qualitative analysis 4h NA 0.92 (0.74-0.98) 0.81 (0.70-0.89) 4.87 (2.94-8.06) 0.10 (0.03-0.39) Cook 2017 54 SD NA 0.92 (0.74-0.98) 0.97 (0.83-0.99) 27.5 (3.99-189.61) 0.09 (0.02-0.33) Cook 2017 54 SD 4h NA 0.90 (0.73-0.97) 0.98 (0.86-1.00) 55.8 (3.56-875.02) 0.10 (0.03-0.33) 6