Enrico Martin

151 Diagnostic accuracy of non-invasive tests Supplementary Table 2 Continued. Study N Characteristic Cut-off Accuracies (95% CI) Sensitivity Specificity pLR nLR Cook 2017 54 NGTDMco NA 0.83 (0.64-0.93) 0.83 (0.66-0.93) 5.00 (2.20-11.35) 0.20 (0.08-0.50) Cook 2017 54 NGTDMco 4h NA 0.79 (0.60-0.91) 0.87 (0.70-0.95) 5.94 (2.33-15.13) 0.24 (0.11-0.53) Cook 2017 54 NGTDMcomp NA 0.79 (0.60-0.91) 0.70 (0.52-0.83) 2.64 (1.47-4.73) 0.30 (0.13-0.67) Cook 2017 54 NGTDMcomp 4h NA 0.79 (0.60-0.91) 0.70 (0.52-0.83) 2.64 (1.47-4.73) 0.30 (0.13-0.67) Cook 2017 54 NGTDMcontr NA 0.83 (0.64-0.93) 0.47 (0.30-0.64) 1.56 (1.07-2.28) 0.36 (0.14-0.95) Cook 2017 54 NGTDMcontr 4h NA 0.50 (0.31-0.69) 0.67 (0.49-0.81) 1.5 (0.79-2.86 ) 0.75 (0.47-1.20) Cook 2017 54 SUVmax/NGTDMcontr NA 0.92 (0.74-0.98) 0.93 (0.79-0.98) 13.75 (3.59-52.74) 0.09 (0.02-0.34) Cook 2017 54 SUVmax/NGTDMcontr 4h NA 0.83 (0.64-0.93) 0.90 (0.74-0.97) 8.33 (2.81-24.74) 0.19 (0.08-0.46) ADC: apparent diffusion coefficient, ADCmean: mean ADC of tumors, ADCmin: minimum ADC of tumors, CE T1-W : target sign on static post contrast sequence; CI: confidence interval, D: diffusion coefficient, f: perfusion fraction, FOE: first-order entropy, FOU: first-order uniformity, GLCMcon: grey-level co-occurrence matrices contrast, GLCMen: grey-level co-occurrence matrices entropy, GLCMhomo: grey-level co-occurrence matrices homogeneity, GLCMun: grey-level co-occurrence matrices uniformity, HISUV: SUV-based heterogeneity index obtained by dividing intratumoral SUVmax by SUVmean of that lesion, MRI: magnetic resonance imaging, MRI 1 feature: perilesional edema or cystic degeneration/necrosis or irregular margins, MRI 2 features: two of the following features: perilesional edema, cystic degeneration/necrosis, and irregular margins, MRI 3 features: perilesional edema and cystic degeneration/necrosis and irregular margins, N: number of patients, NA: not applicable, NGTDMbus: neighbourhood grey-tone difference matrices busyness, NGTDMco: neighbourhood grey-tone difference matrices coarseness, NGTDMcomp: neighbourhood grey-tone difference matrices complexity, NGTDMcontr: neighbourhood grey-tone difference matrices contrast, nLR: negative likelihood ratio, PET-CT: positron emission tomography – computed tomography, pLR: positive likelihood ratio, SD: standard deviation of heterogeneity, Sens: sensitivity, Spec: specificity, SULmax: maximum standardized uptake value derived for lean body, SULmax/liver: lesion uptake adjusted to mean liver activity, SUV: standardized uptake volume, SUVmax: maximum standardized uptake volume, SUVmean: mean standardized uptake volume, SUVpeak: peak standardized uptake volume, TMA fraction: quantitative trimethylamine fraction, TMA peak: qualitative presence of trimethylamine peak, TMTV: total metabolic tumor volume, WB-TMTV: whole-body total metabolic tumor volume. 6