Enrico Martin

152 Chapter 6 Supplementary Table 3 Subgroup analyses of meta-analyses Characteristic Subgroup N Pooled accuracies (95% CI) Sensitivity Specificity MRI Ill-defined margins Total number of lesions <50 5 0.66 (0.52-0.78) 0.91 (0.79-0.98) ≥50 4 0.38 (0.27-0.52) 0.95 (0.87-0.99) Prevalence MPNST ≤33% 3 0.50 (0.27-0.73) 0.98 (0.94-1.00) >33% 6 0.53 (0.39-0.69) 0.88 (0.80-0.95) NF1 patients only Yes 3 0.54 (0.32-0.75) 0.94 (0.80-0.99) No 6 0.51 (0.36-0.68) 0.93 (0.83-0.99) Symptomatic lesions only Yes 2 0.67 (0.48-0.83) 0.86 (0.46-1.00) No 4 0.51 (0.36-0.66) 0.97 (0.87-1.00) Histologically proven only Yes 7 0.54 (0.41-0.69) 0.90 (0.82-0.96) No 2 0.45 (0.20-0.71) 0.98 (0.94-1.00) Perilesional edema Total number of lesions <50 3 0.67 (0.26-0.94) 0.88 (0.57-1.00) ≥50 2 0.60 (0.18-0.95) 0.99 (0.95-1.00) Prevalence MPNST ≤33% 3 0.80 (0.55-0.94) 0.95 (0.80-1.00) >33% 2 0.44 (0.18-0.76) 0.98 (0.83-1.00) NF1 patients only Yes 1 0.89 (0.56-0.99) 0.97 (0.80-0.99) No 4 0.55 (0.36-0.75) 0.92 (0.82-0.99) Symptomatic lesions only Yes 0 NA NA No 2 NA NA Histologically proven only Yes 3 0.43 (0.25-0.65) 1.00 (1.00-1.00) No 2 0.88 (0.69-0.97) 0.83 (0.08-1.00) Cystic changes Total number of lesions <50 4 0.69 (0.48-0.85) 0.58 (0.36-0.81) ≥50 3 0.28 (0.09-0.47) 0.98 (0.93-1.00) Prevalence MPNST ≤33% 4 0.65 (0.41-0.86) 0.71 (0.25-0.97) >33% 3 0.22 (0.04-0.48) 0.93 (0.70-1.00) NF1 patients only Yes 4 0.56 (0.22-0.86) 0.65 (0.30-0.91) No 3 0.38 (0.06-0.76) 0.97 (0.89-1.00) Symptomatic lesions only Yes 0 NA NA No 4 NA NA Histologically proven only Yes 5 0.62 (0.38-0.82) 0.66 (0.44-0.86) No 2 0.18 (0.02-0.47) 0.99 (0.95-1.00) Heterogeneity on T1 Total number of lesions <50 2 0.78 (0.58-0.96) 0.48 (0.02-0.97) ≥50 1 0.83 (0.46-0.99) 0.49 (0.01-0.99) Prevalence MPNST ≤33% 2 0.92 (0.72-0.99) 0.26 (0.03-0.59) >33% 1 0.63 (0.38-0.83) 0.91 (0.53-1.00) NF1 patients only Yes 2 0.70 (0.53-0.84) 0.70 (0.38-0.95) No 1 1.00 (1.00-1.00) 0.08 (0.02-0.39) Symptomatic lesions only Yes 1 0.70 (0.53-0.84) 0.70 (0.38-0.95) No 2 1.00 (1.00-1.00) 0.08 (0.00-0.39) Histologically proven only Yes 2 0.78 (0.58-0.96) 0.48 (0.02-0.97) No 1 0.84 (0.46-0.99) 0.49 (0.01-0.99)