Enrico Martin

153 Diagnostic accuracy of non-invasive tests Supplementary Table 3 Continued. Characteristic Subgroup N Pooled accuracies (95% CI) Sensitivity Specificity Heterogeneity on T2 Total number of lesions <50 2 0.65 (0.38-0.86) 0.49 (0.08-0.91) ≥50 3 0.85 (0.70-0.95) 0.54 (0.15-0.89) Prevalence MPNST ≤33% 4 0.77 (0.62-0.88) 0.54 (0.24-0.82) >33% 1 0.80 (0.57-0.94) 0.44 (0.05-0.91) NF1 patients only Yes 2 0.89 (0.68-0.98) 0.58 (0.12-0.94) No 3 0.72 (0.52-0.87) 0.47 (0.11-0.86) Symptomatic lesions only Yes 0 NA NA No 4 NA NA Histologically proven only Yes 1 0.45 (0.18-0.75) 0.36 (0.02-0.89) No 3 0.85 (0.71-0.94) 0.61 (0.24-0.90) Tumor enhancement Total number of lesions <50 4 0.59 (0.43-0.73) 0.88 (0.67-0.98) ≥50 2 0.74 (0.49-0.91) 0.61 (0.18-0.93) Prevalence MPNST ≤33% 4 0.69 (0.52-0.83) 0.70 (0.43-0.89) >33% 2 0.56 (0.36-0.74) 0.96 (0.79-1.00) NF1 patients only Yes 2 0.74 (0.49-0.91) 0.61 (0.18-0.93) No 4 0.59 (0.43-0.73) 0.88 (0.67-0.98) Symptomatic lesions only Yes 1 0.55 (0.27-0.81) 0.67 (0.52-1.00) No 3 0.63 (0.44-0.80) 0.66 (0.41-0.86) Histologically proven only Yes 3 0.52 (0.34-0.68) 0.90 (0.68-0.99) No 3 0.76 (0.58-0.89) 0.67 (0.29-0.93) Intratumoral lobulation Total number of lesions <50 3 0.67 (0.48-0.82) 0.86 (0.75-0.94) ≥50 2 0.40 (0.20-0.64) 0.90 (0.82-0.95) Prevalence MPNST ≤33% 3 0.47 (0.28-0.68) 0.91 (0.84-0.95) >33% 2 0.67 (0.45-0.84) 0.81 (0.65-0.92) NF1 patients only Yes 3 0.50 (0.31-0.69) 0.89 (0.81-0.94) No 2 0.70 (0.43-0.90) 0.87 (0.73-0.90) Symptomatic lesions only Yes 1 0.63 (0.39-0.83) 0.82 (0.60-0.95) No 3 0.47 (0.29-0.66) 0.91 (0.85-0.95) Histologically proven only Yes 3 0.67 (0.50-0.81) 0.87 (0.76-0.93) No 2 0.41 (0.22-0.62) 0.90 (0.83-0.95) Absence of split-fat sign Total number of lesions <50 2 0.79 (0.55-0.94) 0.52 (0.29-0.77) ≥50 1 0.70 (0.46-0.88) 0.30 (0.08-0.62) Prevalence MPNST ≤33% 1 1.00 (1.00-1.00) 0.33 (0.16-0.54) >33% 2 0.69 (0.53-0.83) 0.46 (0.31-0.64) NF1 patients only Yes 1 0.65 (0.33-0.89) 0.75 (0.51-0.91) No 2 0.78 (0.59-0.91) 0.30 (0.19-0.44) Symptomatic lesions only Yes 1 0.65 (0.33-0.89) 0.75 (0.51-0.91) No 2 0.78 (0.59-0.91) 0.30 (0.19-0.44) Histologically proven only Yes 3 NA NA No 0 NA NA 6