Enrico Martin

154 Chapter 6 Supplementary Table 3 Continued. Characteristic Subgroup N Pooled accuracies (95% CI) Sensitivity Specificity Absence of target sign Total number of lesions <50 3 1.00 (1.00-1.00) 0.31 (0.11-0.59) ≥50 4 0.88 (0.70-0.98) 0.35 (0.16-0.58) Prevalence MPNST ≤33% 4 0.84 (0.65-0.96) 0.41 (0.20-0.63) >33% 3 1.00 (1.00-1.00) 0.24 (0.08-0.49) NF1 patients only Yes 4 0.87 (0.73-0.95) 0.51 (0.42-0.59) No 3 1.00 (1.00-1.00) 0.12 (0.06-0.21) Symptomatic lesions only Yes 1 1.00 (1.00-1.00) 0.65 (0.28-0.92) No 5 0.90 (0.77-0.97) 0.32 (0.18-0.48) Histologically proven only Yes 4 1.00 (1.00-1.00) 0.22 (0.09-0.40) No 3 0.78 (0.55-0.94) 0.48 (0.27-0.71) Irregular shape Total number of lesions <50 3 0.34 (0.10-0.62) 0.80 (0.69-0.88) ≥50 1 0.50 (0.12-0.88) 0.85 (0.72-0.93) Prevalence MPNST ≤33% 3 0.25 (0.10-0.44) 0.84 (0.76-0.90) >33% 1 0.77 (0.51-0.93) 0.71 (0.49-0.88) NF1 patients only Yes 2 0.65 (0.25-0.92) 0.80 (0.58-0.93) No 2 0.08 (0.00-0.36) 0.83 (0.63-0.95) Symptomatic lesions only Yes 1 0.76 (0.51-0.93) 0.71 (0.48-0.88) No 3 0.25 (0.10-0.44) 0.84 (0.76-0.90) Histologically proven only Yes 3 0.34 (0.10-0.62) 0.80 (0.69-0.88) No 1 0.50 (0.12-0.88) 0.85 (0.72-0.93) Tumor size Total number of lesions <50 2 0.61 (0.42-0.80) 0.91 (0.83-0.96) ≥50 1 0.82 (0.59-0.95) 0.72 (0.53-0.86) Prevalence MPNST ≤33% 1 0.50 (0.29-0.71) 0.92 (0.84-0.97) >33% 2 0.84 (0.68-0.94) 0.77 (0.63-0.88) NF1 patients only Yes 1 0.83 (0.59-0.95) 0.72 (0.53-0.86) No 2 0.61 (0.42-0.80) 0.91 (0.83-0.96) Symptomatic lesions only Yes 0 NA NA No 2 NA NA Histologically proven only Yes 2 0.61 (0.42-0.80) 0.91 (0.83-0.96) No 1 0.83 (0.59-0.95) 0.72 (0.53-0.86) Qualitative assessment Total number of lesions <50 0 NA NA ≥50 3 NA NA Prevalence MPNST ≤33% 3 NA NA >33% 0 NA NA NF1 patients only Yes 0 NA NA No 3 NA NA Symptomatic lesions only Yes 0 NA NA No 2 NA NA Histologically proven only Yes 2 0.73 (0.56-0.86) 0.89 (0.80-0.95) No 1 0.61 (0.29-0.87) 0.96 (0.89-0.99)