Enrico Martin

155 Diagnostic accuracy of non-invasive tests Supplementary Table 3 Continued. Characteristic Subgroup N Pooled accuracies (95% CI) Sensitivity Specificity PET SUVmax Total number of lesions <50 5 0.93 (0.84-0.98) 0.88 (0.79-0.94) ≥50 8 0.95 (0.90-0.98) 0.79 (0.71-0.85) Prevalence MPNST ≤33% 6 0.93 (0.87-0.98) 0.77 (0.68-0.85) >33% 7 0.95 (0..90-0.98) 0.86 (0.78-0.92) Symptomatic lesions only Yes 4 1.00 (1.00-1.00) 0.81 (0.68-0.92) No 5 0.94 (0.84-0.99) 0.80 (0.68-0.89) Histologically proven only Yes 4 0.90 (0.81-0.96) 0.87 (0.71-0.92) No 9 0.96 (0.92-0.99) 0.81 (0.74-0.87) Tumor-to-liver ratio Total number of lesions <50 1 0.88 (0.66-0.98) 0.81 (0.54-0.95) ≥50 6 0.93 (0.88-0.97) 0.79 (0.70-0.86) Prevalence MPNST ≤33% 5 0.93 (0.86-0.98) 0.79 (0.68-0.88) >33% 2 0.90 (0.73-0.98) 0.77 (0.55-0.92) Symptomatic lesions only Yes 0 NA NA No 4 NA NA Histologically proven only Yes 2 0.90 (0.78-0.97) 0.77 (0.58-0.91) No 5 0.93 (0.87-0.97) 0.79 (0.70-0.87) Qualitative assessment Total number of lesions <50 1 1.00 (1.00-1.00) 0.73 (0.38-0.94) ≥50 4 0.93 (0.86-0.97) 0.83 (0.73-0.91) Prevalence MPNST ≤33% 3 0.92 (0.83-0.98) 0.85 (0.72-0.94) >33% 2 0.96 (0.84-1.00) 0.72 (0.45-0.91) Symptomatic lesions only Yes 2 0.93 (0.80-0.99) 0.90 (0.78-0.97) No 3 0.94 (0.84-0.99) 0.77 (0.65-0.87) Histologically proven only Yes 0 NA NA No 5 NA NA PET-CT individual patient-level data SUVmax >3.5 Total number of lesions <50 10 0.91 (0.80-0.98) 0.74 (0.60-0.86) ≥50 1 1.00 (1.00-1.00) 0.55 (0.17-0.89) Prevalence MPNST ≤33% 4 0.76 (0.30-0.98) 0.79 (0.54-0.95) >33% 7 0.97 (0.90-1.00) 0.69 (0.49-0.86) Symptomatic lesions only Yes 4 0.72 (0.41-0.94) 0.93 (0.84-0.98) No 6 0.98 (0.90-1.00) 0.52 (0.38-0.65) Histologically proven only Yes 4 0.95 (0.77-1.00) 0.59 (0.31-0.84) No 7 0.93 (0.78-1.00) 0.78 (0.62-0.91) CI: credible interval, MPNST: malignant peripheral nerve sheath tumor, MRI: magnetic resonance imaging, N: number of studies, NA: not applicable, NF1: neurofibromatosis type 1, PET-CT: positron emission tomography – computed tomography, SUVmax: maximum standardized uptake volume 6