Enrico Martin

167 Emerging therapeutic targets Table 1 Continued. Author, year Model Regimen Pathway Tissue NF1 a Outcome Growth b Survival c Metastasis d Antoszczyk, 2014 OXM, AA G47∆-IL12/PF4 oHSV S462 S NA M2 NA NA M3 NA NA Deyle, 2015 XM MV-NIS oMV ST88-14 NF1 NA S462TY NF1 NA Currier, 2017 XM HSV1716 + alisertib oHSV, AURKA S462TY NF1 NA Other Mashour, 2005 AA DHA Apoptosis 32-5-30 NA NA Ghadimi, 2012 XM Sepantromium bromide Survivin MPNST724 S NA NA STS26T S NA Wang, 2012 XM Triptolide Apoptosis STS26T S NA NA Demestre, 2013 XM PEDF Multi- antitumor S462 NF1 NA NA Patel, 2015 XM C75 FAS STS26T S NA NA Zewdu, 2016 XM Verticillin A Apoptosis MPNST724 S NA NA Ikuta, 2017 XM MU Hyaluronan synthesis sNF96.2 NF1 NA NA Semenova, 2017 XM Nifedipine Ca 2+ -channel S462TY NF1 NA NA a : NF1 patient cells or sporadic patient cells, b : either volume, weight, or area, low activity (light gray), intermediate activity (dark gray), high activity (black), c : increased survival (black) d : less metastases (black) AA: auto- and/or allograft mouse model, AURKA: aurora kinase A, BET: bromo- and extra-terminal domain, CAPE: caffeic acid phenethyl ester, CDK: cyclin-dependent kinase, CXCR4: CXC-chemokine receptor 4, DHA: docosahexaenoic acid, DZNep: 3-deazaneplanocin A, EGFR: epidermal growth factor receptor, ER: estrogen receptor, EZH2: enhancer of zeste homolog 2, FAS: fatty acid synthase, GEMM: genetically modified mouse model, HDAC: histone deacetylase, Hsp90: heat shock protein 90, JAK2: Janus kinase 2, MEK: mitogen-activated protein kinase kinase, MPNST: malignant peripheral nerve sheath tumor, mTOR: mammalian target of rapamycin, MU: 4-methylumbelliferone, NA: not applicable/available, NF1: neurofibromatosis type 1, NPcis: mutation of NF1 and p53 gene on both alleles, oHSV: oncolytic herpes simplex virus, oMV: oncolytic measles virus, OXM: orthotopic xenograft mouse model, PARP: poly (ADP-ribose) polymerase, PEDF: pigment epithelium-derived factor, PDK1: phosphoinositide-dependent kinase-1, PDX: patient-derived xenograft, PI3K: phosphoinositide 3-kinase, PLK1: polo-like kinase 1, PTT: phototermal therapy, S: sporadic, STAT3: signal transducer and activator of transcription 3, XM: xenograft mouse model, XPO1: exportin 1, ZFM: genetically engineered zebrafish model 7