Enrico Martin

194 Chapter 8 Table 1 Study characteristics of included studies. Study, year Patients Reconstructions High grade tumors Other treatment Functional outcome measure F-U (mo) Total UE LE FFMT Tendon Nerve RTx Cx Doi 1999 17 11.8% 88.2% 100% 29.4% 5.9% Yes 0% 64.7% MSTS, MRC, ROM lag, walking aid 60 (27-106) Fischer 2015 43 0% 100% 0% 100% 0% NA 41.2% ROM, strength, Karnofsky, QoL, satisfaction, walking aid 66 (22-107) Grinsell 2012 18 16.7% 82.3% 100% 0% 11.1% Yes 100% 0% MSTS, MRC, LEFS, DASH 18 (6-42) Gunterberg 1980 2 0% 100% 0% 100% 0% No NA NA ROM, strength 40 (36-44) Innocenti 2009 10 0% 100% 100% 40% 0% Yes 80% 70% MSTS, MRC 69 (21-136) Mehrara 2008 7 100% 0% 0% 71.4% 57.1% NA 28.6% 0% MSTS 47 ( NA ) Melendez 2001 6 0% 100% 0% 0% 100% NA 83.3% 50% MRC, S 12 (5-42) Mirous 2016 3 100% 0% 0% 100% 66.7% Yes 33.3% 66.7% MSTS, DASH, VAS 54 (12-156) Mundinger 2014 12 100% 0% 0% 100% 0% Yes 83.3% NA TESS 43 ( NA ) Muramatsu 2009 4 100% 0% 100% 0% 0% Yes 0% NA MSTS 69 (12-173) Muramatsu 2014 4 100% 0% 0% 100% 0% Yes NA NA MSTS, MRC, ROM 50 (12-106) Stranix 2017 4 0% 100% 100% 0% 0% Yes NA NA MSTS 22 (20-36) Tokumoto 2018 2 0% 100% 0% 0% 100% Yes NA NA MRC, S 12 (3-24) Walley 2017 2 0% 100% 100% 0% 0% Yes 100% 50% MSTS, KSS, ROM, MRC, walking aid 19 (17-21) Total 134 26.1% 74.9% 41.0% 58.2% 12.7% 60.3% 49.4% Cx: chemotherapy DASH: disability of arm, shoulder, and hand, FFMT: free functioning muscle transfer, F-U: follow-up, KSS: knee society score, LE: lower extremity, mo: months, MRC: medical research council muscle grade, MSTS: musculoskeletal tumor society rating scale, N: number of, NA: not available, No. pt: number of patients, QoL: quality of life, ROM: range of motion, RTx: radiotherapy, S: sensibility, TESS: Toronto extremity salvage score, UE: upper extremity, VAS: visual analog scale