Enrico Martin

21 Introduction and thesis outline 31. Miettinen MM, Antonescu CR, Fletcher CDM, et al. Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview. Hum Pathol . 2017;67:1-10. doi:10.1016/j.humpath.2017.05.010 32. Kolberg M, Holand M, Agesen TH, et al. Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro Oncol . 2013;15(2):135-147. doi:10.1093/neuonc/ nos287 33. van Noesel MM, Orbach D, Brennan B, et al. Outcome and prognostic factors in pediatric malignant peripheral nerve sheath tumors: An analysis of the European Pediatric Soft Tissue Sarcoma Group (EpSSG) NRSTS-2005 prospective study. Pediatr Blood Cancer . 2019;66(10):e27833. doi:10.1002 / pbc.27833 34. Meis JM, Enzinger FM, Martz KL, Neal JA. Malignant peripheral nerve sheath tumors (malignant schwannomas) in children. Am J Surg Pathol . 1992;16(7):694-707. 35. Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Amputation for extremity soft tissue sarcoma does not increase overall survival: a retrospective cohort study. Eur J Surg Oncol . 2012;38(12):1178-1183. doi:10.1016/j. ejso.2012.08.024 36. Ghert MA, Abudu A, Driver N, et al. The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremity. Ann Surg Oncol . 2005;12(1):10-17. doi:10.1007/s10434-004- 1171-3 37. Jones KB, Ferguson PC, Deheshi B, et al. Complete femoral nerve resection with soft tissue sarcoma: functional outcomes. Ann Surg Oncol . 2010;17(2):401-406. doi:10.1245/s10434-009-0745-5 38. Davis AM, Sennik S, Griffin AM, et al. Predictors of functional outcomes following limb salvage surgery for lower- extremity soft tissue sarcoma. J Surg Oncol . 2000;73(4):206-211. 39. Bell RS, O’Sullivan B, Nguyen C, et al. Fractures following limb-salvage surgery and adjuvant irradiation for soft- tissue sarcoma. Clin Orthop Relat Res . 1991;(271):265-271. 40. Brooks AD, Gold JS, Graham D, et al. Resection of the sciatic, peroneal, or tibial nerves: assessment of functional status. Ann Surg Oncol . 2002;9(1):41-47. 41. Payne CE, Hofer SOP, Zhong T, Griffin AC, Ferguson PC, Wunder JS. Functional outcome following upper limb soft tissue sarcoma resection with flap reconstruction. J Plast Reconstr Aesthet Surg . 2013;66(5):601-607. doi:10.1016/j. bjps.2013.01.034 42. Davidge KM, Wunder J, Tomlinson G, Wong R, Lipa J, Davis AM. Function and health status outcomes following soft tissue reconstruction for limb preservation in extremity soft tissue sarcoma. Ann Surg Oncol . 2010;17(4):1052-1062. doi:10.1245/ s10434-010-0915-5 43. Gerrand CH, Wunder JS, Kandel RA, et al. Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence. J Bone Joint Surg Br . 2001;83(8):1149-1155. 44. Clarkson PW, Griffin AM, Catton CN, et al. Epineural dissection is a safe technique that facilitates limb salvage surgery. Clin Orthop Relat Res . 2005;438:92-96. 45. Mundinger GS, Prucz RB, Frassica FJ, Deune EG. Concomitant upper extremity soft tissue sarcoma limb-sparing resection and functional reconstruction: assessment of outcomes and costs of surgery. Hand (N Y) . 2014;9(2):196-204. doi:10.1007/s11552-013-9567-9 46. Saint-Cyr M, Langstein HN. Reconstruction of the hand and upper extremity after tumor resection. J Surg Oncol . 2006;94 (6):490 -503. doi:10.1002 / jso.20486 47. Moberg E. Objective Methods of for Determining in the the Sensibility. J Bone Jt Surg . 1958;48B(3):454-476. 1

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