Enrico Martin

34 Chapter 2 Table 3 Univariable and multivariable Cox analysis of overall survival in all primary MPNST. Variable Definition Univariable Analysis Multivariable Analysis HR 95% CI P HR 95% CI P Age 19-59 Ref. Ref. <18 0.84 0.70-1.02 0.071 0.80 0.66-0.97 0.022 60+ 1.65 1.49-1.84 <0.001 1.79 1.60-1.99 <0.001 Sex Female Ref. Ref. Male 1.18 1.07-1.30 0.001 1.15 1.04-1.27 0.006 Race White Ref. Ref. Black 1.19 1.03-1.37 0.018 1.22 1.05-1.41 0.008 Asian & other 0.94 0.78-1.14 0.528 0.93 0.77-1.12 0.435 Unknown 0.32 0.10-0.99 0.047 0.42 0.13-1.30 0.132 Therapy Sx only Ref. Ref. RTx only 2.50 2.01-3.11 <0.001 2.07 1.65-2.59 <0.001 Sx and RTx 1.17 1.05-1.31 0.006 1.09 0.97-1.23 0.153 None 1.63 1.35-1.96 <0.001 1.58 1.31-1.91 <0.001 Unknown 1.71 1.42-2.06 <0.001 1.54 1.27-1.87 <0.001 Surgery GTR Ref. PR 1.00 0.87-1.15 0.989 Biopsy 1.55 1.13-2.13 0.006 No Sx 1.88 1.58-2.25 <0.001 Sx NOS 1.09 0.95-1.25 0.238 Unknown 1.93 1.54-2.43 <0.001 Radiation Sequence No Sx or no RTx Ref. Adjuvant RTx 1.01 0.91-1.13 0.821 Neoadjuvant RTx 1.01 0.79-1.28 0.949 RTx b/a Sx 0.71 0.38-1.32 0.277 Intraoperative RTx 0.60 0.27-1.36 0.210 Unknown 1.20 0.54-2.68 0.658 Tumor Location Limbs Ref. Ref. Intracranial 0.80 0.61-1.07 0.128 0.74 0.55-0.99 0.045 Spinal 1.27 0.94-1.70 0.115 1.28 0.94-1.72 0.113 H&N 1.18 1 .00-1.40 0.052 1.27 1 .07-1.52 0.007 Core 1.68 1.49-1.89 <0.001 1.58 1.40-1.78 <0.001 NOS & Unknown 2.07 1.69-2.54 <0.001 1.80 1.45-2.23 <0.001 Tumor Grade I Ref. Ref. II 1.34 0.94-1.89 0.102 1.33 0.94-1.89 0.106 III 2.91 2.08-4.06 <0.001 2.74 1.96-3.84 <0.001 IV 3.69 2.67-5.10 <0.001 3.24 2.33-4.49 <0.001 Unknown 2.53 1.86-3.45 <0.001 2.34 1.71-3.19 <0.001 Tumor Size ≤50 mm Ref. Ref. >50 mm 2.43 2.09-2.82 <0.001 2.26 1.93-2.64 <0.001 Unknown 2.03 1.75-2.36 <0.001 1.91 1.63-2.22 <0.001 b/a: before and after, GTR: gross total resection, H&N: head and neck, HR: hazard ratio, intraop: intraoperatively, mm: millimeter, N: number, NA: not applicable, NOS: not otherwise specified, PR: partial resection, Ref.: reference, RTx: radiotherapy, Sx: surgery