Enrico Martin

35 Treatment and survival differences across tumor sites Table 4 Multivariable Cox analysis of all primary MPNST including either radiation sequence of extent of surgery. Variable Definition Univariable Analysis Multivariable Analysis HR 95% CI P HR 95% CI P Age 19-59 Ref. Ref. <18 0.79 0.66-0.97 0.020 0.80 0.66-0.97 0.023 60+ 1.79 1.60-1.99 <0.001 1.78 1.59-1.98 <0.001 Sex Female Ref. Ref. Male 1.15 1.04-1.27 0.008 1.16 1.05-1.28 0.005 Race White Ref. Ref. Black 1.27 1.09-1.46 0.002 1.23 1.06-1.42 0.006 Asian & other 0.93 0.77-1.12 0.432 0.93 0.77-1.12 0.431 Unknown 0.42 0.14-1.32 0.137 0.40 0.13-1.26 0.117 Surgery GTR Ref. PR 1.10 0.96-1.27 0.174 Biopsy 1.56 1.13-2.14 0.007 No Sx 1.93 1.60-2.32 <0.001 Sx NOS 1.16 1.00-1.35 0.055 Unknown 1.97 1.53-2.52 <0.001 Radiation Sequence No Sx or no RTx Ref. Adjuvant RTx 0.97 0.86-1.09 0.569 Neoadjuvant RTx 0.85 0.67-1.09 0.209 RTx b/a Sx 0.74 0.40-1.39 0.355 Intraoperative RTx 0.72 0.32-1.60 0.418 Unknown 0.98 0.44-2.19 0.958 Tumor Location Limbs Ref. Ref. Intracranial 0.88 0.66-1.17 0.380 0.74 0.55-1.00 0.046 Spinal 1.23 0.91-1.66 0.177 1.31 0.97-1.77 0.084 H&N 1.32 1.11-1.58 0.002 1.28 1.08-1.53 0.005 Core 1.62 1.44-1.83 <0.001 1.57 1.39-1.77 <0.001 NOS & Unknown 1.99 1.61-2.45 <0.001 1.73 1.40-2.15 <0.001 Tumor Grade I Ref. Ref. II 1.33 0.94-1.88 0.113 1.35 0.96-1.92 0.101 III 2.83 2.02-3.96 <0.001 2.82 2.02-3.95 <0.001 IV 3.40 2.45-4.71 <0.001 3.40 2.45-4.71 <0.001 Unknown 2.44 1.79-3.34 <0.001 2.32 2.32-1.69 <0.001 Tumor Size ≤50 mm Ref. Ref. >50 mm 2.33 2.00-2.72 <0.001 2.33 1.99-2.72 <0.001 Unknown 1.93 1.65-2.25 <0.001 1.82 1.55-2.13 <0.001 b/a: before and after, GTR: gross total resection, H&N: head and neck, HR: hazard ratio, intraop: intraoperatively, mm: millimeter, N: number, NA: not applicable, NOS: not otherwise specified, PR: partial resection, Ref.: reference, RTx: radiotherapy, Sx: surgery 2