Enrico Martin

39 Treatment and survival differences across tumor sites sites of origin may, therefore, lead to a better understanding of these rare tumors. In the future, large databases with prospective registration could be set up that track all outcomes relevant to MPNSTs through multicenter interdisciplinary efforts. Exact clinicopathological differences between tumor sites and between pediatric and adult tumors should be investigated. This could help formulate specific treatment strategies to improve outcomes for these patients. Conclusion This study of the SEER database shows that intracranial and pediatric MPNSTs are associated with better overall survival, independent from treatment and other tumor specific factors. Worst prognosis is seen in core sites and tumors arising in the head and neck. Treatment modalities and extent of resection also vary slightly among tumor sites. Apart from tumor origin, older age, male gender, black race, higher tumor grade and large tumors may be associated with decreased survival. 2