Enrico Martin

45 Treatment and survival differences across tumor sites Supplemental Table 3 Continued. Variable Definition Intracranial HR (95% CI) P Spinal HR (95% CI) P H&N HR (95%CI) P Radiation Sequence No Sx or no RTx Ref. Ref. Ref. RTx after Sx 1.96 (1.06-3.62) 0.032 3.23 (1.81-5.79) <0.001 1.13 (0.84-1.53) 0.411 RTx before Sx NA NA 4.83 (0.64-36.57) 0.127 0.96 (0.36-2.61) 0.942 RTx b/a Sx NA NA NA NA 2.60 (0.96-7.07) 0.061 Intraoperative RTx NA NA NA NA NA NA Unknown NA NA NA NA NA NA Tumor Grade I Ref. Ref. Ref. II NA NA 0.62 (0.06-6.82) 0.692 2.48 (0.86-7.12) 0.093 III NA NA 5.69 (0.51-63.99) 0.159 5.30 (1.80-15.66) 0.003 IV NA NA 1.69 (0.20-14.54) 0.631 6.66 (2.33-19.03) <0.001 Unknown NA NA 0.62 (0.08-4.36) 0.634 3.88 (1.43-10.54) 0.008 Tumor Size ≤50 mm Ref. Ref. Ref. >50 mm 3.49 (1.37-8.91) 0.009 5.26 (1.79-15.50) 0.003 2.25 (1.53-3.33) <0.001 Unknown 1.92 (1.00-3.72) 0.051 3.22 (1.35-7.67) 0.008 1.64 (1.17-2.29) 0.004 b/a: before and after, GTR: gross total resection, H&N: head and neck, HR: hazard ratio, intraop: intraoperatively, mm: millimeter, N: number, NA: not applicable, NOS: not otherwise specified, PR: partial resection, Ref.: reference, RTx: radiotherapy, Sx: surgery 2