Enrico Martin

47 Treatment and survival differences across tumor sites Supplemental Table 4 Continued. Variable Definition Limbs HR (95% CI) P Core HR (95% CI) P NOS & Unknown HR (95%CI) P Radiation Sequence No Sx or no RTx Ref. Ref. Ref. RTx after Sx 1.04 (0.84-1.28) 0.733 0.83 (0.70-0.99) 0.038 1.35 (0.89-2.06) 0.160 RTx before Sx 1.08 (0.74 (1.58) 0.686 0.97 (0.69-1.39) 0.883 0.83 (0.26-2.64) 0.758 RTx b/a Sx 0.58 (0.25-1.82) 0.437 0.66 (0.16-2.64) 0.556 NA NA Intraoperative RTx 1.17 (0.37-3.65) 0.789 0.65 (0.21-2.04) 0.464 NA NA Unknown 2.33 (0.58-9.37) 0.234 0.89 (0.29-2.78) 0.845 1.43 (0.20-10.31) 0.723 Tumor Grade I Ref. Ref. Ref. II 1.20 (0.62-2.32) 0.580 1.27 (0.79-2.06) 0.330 1.90 (0.41-8.85) 0.412 III 3.63 (1.98-6.65) <0.001 2.35 (1.47-3.74) <0.001 3.38 (0.76-15.00) 0.109 IV 4.02 (2.21-7.31) <0.001 3.25 (2.09-5.05) <0.001 4.62 (1.01-21.05) 0.048 Unknown 2.69 (1.50-4.82) 0.001 2.51 (1.65-3.83) <0.001 2.47 (0.60-10.10) 0.208 Tumor Size ≤50 mm Ref. Ref. Ref. >50 mm 2.32 (1.78-3.01) <0.001 2.37 (1.87-3.00) <0.001 1.53 (0.64-3.65) 0.339 Unknown 1.58 (1.18-2.11) 0.002 2.28 (1.79-2.91) <0.001 1.31 (0.57-3.01) 0.524 b/a: before and after, GTR: gross total resection, H&N: head and neck, HR: hazard ratio, intraop: intraoperatively, mm: millimeter, N: number, NA: not applicable, NOS: not otherwise specified, PR: partial resection, Ref.: reference, RTx: radiotherapy, Sx: surgery 2