Enrico Martin

77 Treatment and survival in pediatric MPNST B F A E D C Figure 1 Kaplan-Meier curves for overall survival in localized pediatric MPNST. A) Tumor stage at presentation (metastatic vs localized) B) NF1 status C) tumor size (≤5 cm vs > 5 cm) D) tumor depth (superficial vs deep of the fascia) E) resection margin (R0 vs R1 vs R2/biopsy) F) time period (1989-2005 vs 2006-2017) disease had a 1-year survival rate of 33.3% (SE: 19.2%) compared to 82.8% (SE: 4.7%, P<0.05) presenting with localized disease ( Figure 1 ). In localized pediatric patients only, NF1 patients had lower 5-year survival rates (52.4%, SE: 10.1%) compared to non-NF1 children (75.8%, SE: 7.1%, p<0.05). Also, estimated 5-year survival rates were 4