Klaske van Sluis

CHAPTER 3 Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study Abstract Purpose: The purpose of this study is to assess the general course of acoustic, patient rated, and clinician rated voice outcomes from pre- up to twelve months post-laryngectomy. Methods: Patients admitted to a total laryngectomy in five participating hospitals in Australia and The Netherlands were included. Assessments took place at pre-, 3 months, 6 months, and twelve months post-surgery. Voice out- comes are evaluated with the Acoustic Voice Quality Index (AVQI), perceptual scales, and patient reported outcome measures including VHI-10 and EQ-5D- 5L. Statistical analyses include descriptive statistics, t-tests (pre- to 6 months post-surgery), Linear Mixed Effect models. Results: The study included 43 participants. A significant worsening of AVQI is seen from pre- to post-surgery evaluated with t-test ( p <.001). The Lin- 0 Appeared as: van Sluis, K.E., van Son, R.J.J.H., van der Molen, L., McGuinness, A.J., Palme, C.E., Novakovic, D., Stone, D., Natsis, L., Charters, E., Jones, K., Dirven, R., van den Brekel, M.W.M. “Multidimensional evaluation of voice outcomes following total laryngec- tomy: a prospective multicenter cohort study.” European Archives of Oto-Rhino-Laryngoly , 1-14, 2020.