Klaske van Sluis

Voice outcomes following total laryngectomy 53 Patients planned for TL (n= 72) Inclusion period: NCI: April 2015 – May 2018 SYD: March 2017 – May 2019 Excluded (n= 29) ♦ Not meeting inclusion criteria (n= 1) ♦ Declined to participate (n= 8) ♦ Missed by clinician (n= 11) ♦ Out of area, follow-up elsewhere (n= 7) ♦ Excluded from analysis no medical and surgical information, no follow-up (n= 2) Data of (n=43) ♦ Assessment (n=37) ♦ Questionnaires (n=41) ♦ Voice recording (n=40) Included (n=45) Enrollment T 0 - pre assessment T1 - 3 months post T2 - 6 months post T3 - 12 months post Lost to follow-up (n=12) ♦ Palliated / died (n=10) ♦ Declined further participation (n=1) ♦ Referred to hospital out of area (n=1) Data of (n=31) ♦ Assessment (n=28) ♦ Questionnaires (n=26) ♦ Voice recording (n=19) Lost to follow-up (n=2) ♦ Palliated / died (n=2) Data of (n=29) ♦ Assessment (n=27) ♦ Questionnaires (n=24) ♦ Voice recording (n=27) Lost to follow-up (n=6) ♦ Palliated / died (n=1) ♦ Declined further participation (n=3) ♦ Medical complications (n=2) Data of (n=23) ♦ Assessment (n=20) ♦ Questionnaires (n=20) ♦ Voice recording (n=19) Excluded (n= 2) ♦ N o medical information, no follow-up (n= 2) Figure 3.1: Flow-chart of study inclusion and follow-up of participants. 3.3.2 General course of self-reported outcomes and acous- tic voice quality Mean scores for EQ-5D-5L, VHI-10, AVQI, Perc. Voice SLP, and Perc. Voice Pt for the total group and the defined sub-groups for the time points T0 (pre- surgery), T1 (3 months post), T2 (6 months post), and T3 (12 months post) are shown in Table 4. Primary outcome measures show high variation, which is demonstrated by the large standard deviation provided in Table 4. Figure 2 shows the course over time, scaled 0-10, a higher score indicating better outcome. After surgery a worsening of all voice related values is seen, which gradually improves over time. Statistical significance was reached for AVQI (p<.001) for difference of T0 to T2, for the other outcome measures no statis-