Jacky Luiten

Introduction and outline | 11 1 Methods The data for the studies described in the chapters 2, 3, 4 and 5 originate from the southern breast cancer screening region in the Netherlands (BOBZ region, Bevolkings Onderzoek Borstkanker Zuid ). During a two‐year follow‐up period (up to the next biennial screen), the radiology reports, type of biopsy methods with their outcome, breast surgery reports and final histopathology results of all recalled women were collected. The screening organization routinely received the follow‐up data from the hospitals where the women were examined following a recall. To complete 2‐year follow‐up one of the radiologists (LD) and several radiology residents collected additional reports, which had not been received by the screening organization, through visits at these departments. All data were entered into a database, created for quality control of the screening program and scientific purposes, by the radiologist (LD). For Chapter 6, a cohort of women with non‐palpable DCIS in a single center between March 2006 and June 2013 were retrospectively analyzed. Chapter 7 was based on data from the Netherlands Cancer Registry (NCR), which is managed by the Netherlands Comprehensive Cancer Organization (IKNL, Integraal Kankercentrum Nederland ). The NCR contains all new cases of in situ and invasive malignancies and data on patient, tumor and initial treatment characteristics 25 . Data are available on a national level from 1989 onwards. The NCRs main source of information is the nationwide network and registry of histo‐ and cytopathology in the Netherlands (PALGA, Pathologisch Anatomisch Landelijk Geautomatiseerd Archief) 26 .

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