Jacky Luiten

Contents Chapter 1 Introduction and outline 7 Chapter 2 Trends in incidence and tumor grade in screen‐detected 15 ductal carcinoma in situ and invasive breast cancer Chapter 3 Utility of diagnostic breast excision biopsies during two 33 decades of screening mammography Chapter 4 Trends in frequency and outcome of high‐risk breast lesions 47 at core needle biopsy in women recalled at biennial screening mammography, a multiinstitutional study Chapter 5 Recall and outcome of screen‐detected microcalcifications 65 during two decades of mammography screening in the Netherlands national breast screening program Chapter 6 Iodine seeds versus wire guided localization in breast 85 conserving surgery for non‐palpable ductal carcinoma in situ Chapter 7 Patterns of treatment and outcome of ductal carcinoma in situ 95 in the Netherlands Chapter 8 Summary and summary in Dutch – Nederlandse samenvatting 115 Chapter 9 General discussion and future perspectives 127 Valorisation 143 List of publications 151 Curriculum Vitae 155 Acknowledgement ‐ Dankwoord 159