Jacky Luiten

Trends in frequency and outcome of high‐risk breast lesions at CNB |61 4 outcome of these lesions with other studies is limited as they show considerable heterogeneity in the type of biopsy procedures and subtyping of high‐risk lesions. Although we included a large consecutive series of screening mammograms, no more than 329 high‐risk lesions were diagnosed leaving some of the subgroups too small for a proper analysis. Moreover, only multiple (more than one) papillomas in the same breast are associated with a higher risk of developing breast cancer. Unfortunately, we were not able to fully discriminate solitary papilloma from multiple papillomas in all cases, which is a limitation for the papillary lesion group. In conclusion, a significant increase in the proportion of high‐risk lesions detected at CNB was observed, with a concomitant increased excision rate for these lesions resulting in an increasing number of screened women who underwent invasive diagnostic surgical excision with benign outcome at final pathology. Larger studies are needed to define evidence‐based practice recommendations for the management of high‐risk lesions detected at CNB.