Jacky Luiten

90 | Chapter 6 Surgical margins A histologically complete resection of DCIS was achieved in 75 (82%) of 91 patients in the I ‐ 125 GL group compared with 58 (74%) of 78 in the WGL group ( p =0.139; Table 6.2). Focally involved margins were found in 12 patients (13%) and ten patients (13%) respectively ( p =0.944). Resection margins were involved extensively in four patients (4%) following I ‐ 125 GL and ten (13%) after WGL ( p =0.048). Table 6.2 Final histology of surgical resection margins of DCIS. Margin status WGL (n = 78) I ‐ 125 GL (n = 91) Complete resection 58 (74) 75 (82) Focally involved margins 10 (13) 12 (13) Extensively involved margins 10 (13) 4 (4) Values in parentheses are percentages unless indicated otherwise. p=0.048 (extensively involved margins versus complete resection and focally involved margins, χ 2 test). Additional treatment owing to involved margins Eight of the twelve patients with focally involved resection margins in the I ‐ 125 GL group and seven of the ten with focally involved resection margins in the WGL group received additional boost radiotherapy (Table 6.3). All patients with extensively involved resection margins underwent additional surgery by either a re ‐ excision or mastectomy. In the I ‐ 125 GL group, re ‐ excision revealed residual DCIS in three patients and no residual DCIS was detected in one woman who had a mastectomy. In the WGL group, residual DCIS was detected in two of the three women who underwent re ‐ excisions, and four of the seven who had a mastectomy. Table 6.3 Additional local therapy following incomplete resection. WGL (n=78) I ‐ 125 GL (n=91) Focally involved margins (%) Re ‐ excision Breast amputation Boost radiotherapy 10 (13) 2 1 7 12 (13) 4 0 8 Extensively involved margins (%) Re ‐ excision Breast amputation Boost radiotherapy 10 (13) 3 7 0 4 (4) 3 1 0 Values in parentheses are percentages unless indicated otherwise