Jos Jansen

5 125 Screening for abnormal glycosylation in a cohort of adult liver disease patients Conclusion Our screening study did not identify V-ATPase assembly factor defects in a cohort of severe liver disease, but we show that end-stage liver disease is associated with hyperfucosylation of transferrin. We confirm that regular CDG screening with tIEF can be complicated by liver disease, itself is associated with mildly abnormal tIEF profiles Acknowledgments This work was supported by the Dr. Karel-Lodewijk Verleysen Award (JD) and the Dutch Organization for Scientific Research (ZONMW) Medium Investment grant 40-00506-98-9001 (DL) Conflict of Interest All authors state no conflict of interest. Author contributions JJ, MvS, JD and DL design the study. JJ, FZ and KH performed the experiments. BvH, HM, AvdB and JD provided samples and collected data. JJ, JD and DL wrote the manuscript. All authors critically reviewed the manuscript.