Sanne Hoeks

General Introduction 11 1 FIGURE 1. Induction of immunological tolerance in tissue transplants. A, An adult strain A mouse rejects a graft from a strain B mouse. B, If a neonatal strain A mouse is injected with strain B leucocytes (shown in red), when the mouse becomes an adult it fails to reject a strain B graft. C, This neonatally injected strain A mouse rejects grafts from other strains (e.g. strain C) indicating that tolerance is immunologically specific.