Sanne Hoeks

General Discussion 117 7 REFERENCES 1. Pawelec G, Gupta S. Editorial: Immunology of Aging. Front Immunol . 2019;10:1614. doi:10.3389/fimmu.2019.01614 2. Huygens A, Lecomte S, Tackoen M, et al. Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection. J Infect Dis . Aug 2015;212(3):484-94. doi:10.1093/infdis/jiv071 3. Harbeson D, Ben-Othman R, Amenyogbe N, Kollmann TR. Outgrowing the Immaturity Myth: The Cost of Defending From Neonatal Infectious Disease. Front Immunol . 2018;9:1077. doi:10.3389/fimmu.2018.01077 4. Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and cancer. Trends Immunol . Apr 2015;36(4):265- 76. doi:10.1016/j.it.2015.02.008 5. Duggan PJ, Maalouf EF, Watts TL, et al. Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions. Lancet . Nov 2001;358(9294):1699-700. doi:10.1016/s0140- 6736(01)06723-x 6. Luciano AA, Yu H, Jackson LW, Wolfe LA, Bernstein HB. Preterm labor and chorioamnionitis are associated with neonatal T cell activation. PLoS One . Feb 2011;6(2):e16698. doi:10.1371/journal.pone.0016698 7. Crespo M, Martinez DG, Cerissi A, et al. Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity. Pediatr Res . Feb 2012;71(2):136- 43. doi:10.1038/pr.2011.26 8. Rueda CM, Moreno-Fernandez ME, Jackson CM, Kallapur SG, Jobe AH, Chougnet CA. Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function. Eur J Immunol . Sep 2015;45(9):2582-92. doi:10.1002/ eji.201445371 9. Rito DC, Viehl LT, Buchanan PM, Haridas S, Koenig JM. Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis. Pediatr Res . Apr 2017;81(4):639-645. doi:10.1038/pr.2016.254 10. Caron JE, La Pine TR, Augustine NH, Martins TB, Kumánovics A, Hill HR. Severely depressed interleukin-17 production by human neonatal mononuclear cells. Pediatr Res . Dec 2014;76(6):522-7. doi:10.1038/pr.2014.133 11. Netea MG, van der Meer JW. Trained Immunity: An Ancient Way of Remembering. Mar 2017;21(3):297-300. doi:10.1016/j.chom.2017.02.003 12. van der Heijden CDCC, Noz MP, Joosten LAB, Netea MG, Riksen NP, Keating ST. Epigenetics and Trained Immunity. Antioxid Redox Signal . 10 2018;29(11):1023-1040. doi:10.1089/ars.2017.7310 13. Kleinnijenhuis J, Quintin J, Preijers F, et al. Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A . Oct 2012;109(43):17537-42. doi:10.1073/pnas.1202870109 14. Quintin J, Saeed S, Martens JHA, et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Aug 2012;12(2):223-32. doi:10.1016/j.chom.2012.06.006 15. Sanchez-Schmitz G, Levy O. Development of newborn and infant vaccines. Sci Transl Med . Jul 2011;3(90):90ps27. doi:10.1126/scitranslmed.3001880 16. Aaby P, Roth A, Biering-Sørensen S, et al. No evidence of bias in trial showing BCG reduces neonatal mortality. J Infect Dis . Feb 2012;205(3):515-7. doi:10.1093/infdis/jir761 17. Roth A, Jensen H, Garly ML, et al. Lowbirth weight infants and Calmette-Guérin bacillus vaccination at birth: community study from Guinea-Bissau. Pediatr Infect Dis J . Jun 2004;23(6):544-50. doi:10.1097/01.inf.0000129693.81082.a0 18. Levy O, Wynn JL. A prime time for trained immunity: innate immune memory in newborns and infants. Neonatology . 2014;105(2):136-41. doi:10.1159/000356035 19. Arts RJW, Carvalho A, La Rocca C, et al. Immunometabolic Pathways in BCG-Induced Trained Immunity. Cell Rep . 12 2016;17(10):2562-2571. doi:10.1016/j.celrep.2016.11.011 20. Saeed S, Quintin J, Kerstens HH, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science . Sep 2014;345(6204):1251086. doi:10.1126/science.1251086 21. Groh L, Netea MG, Riksen NP, Keating ST. Getting to the marrow of trained immunity. Epigenomics . 09 2018;10(9):1151- 1154. doi:10.2217/epi-2018-0098 22. Torow N, Hornef MW. The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis. J Immunol . 01 2017;198(2):557-563. doi:10.4049/jimmunol.1601253