Sanne Hoeks

Defective neonatal TH17 development and reduced RORC2 mRNA 43 3 REFERENCES 1. Schaub B, Liu J, Schleich I, Höppler S, Sattler C, von Mutius E. Impairment of T helper and T regulatory cell responses at birth. Allergy . Nov 2008;63(11):1438-47. doi:10.1111/j.1398-9995.2008.01685.x 2. Belderbos ME, van Bleek GM, Levy O, et al. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin Immunol . Nov 2009;133(2):228-37. doi:10.1016/j.clim.2009.07.003 3. Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski SM, Chen W. “Default” generation of neonatal regulatory T cells. J Immunol . Jul 2010;185(1):71-8. doi:10.4049/jimmunol.0903806 4. de Roock S, Hoeks SB, Meurs L, et al. Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood. J Allergy Clin Immunol . Dec 2011;128(6):1369-71. doi:10.1016/j. jaci.2011.08.006 5. Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature . May 2006;441(7090):235-8. doi:10.1038/nature04753 6. Nitsche A, Zhang M, Clauss T, Siegert W, Brune K, Pahl A. Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors. BMC Immunol . Aug 2007;8:18. doi:10.1186/1471-2172-8-18 7. Cosmi L, De Palma R, Santarlasci V, et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med . Aug 2008;205(8):1903-16. doi:10.1084/jem.20080397 8. van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity . Oct 2007;27(4):660-9. doi:10.1016/j.immuni.2007.08.013 9. Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell . Sep 2006;126(6):1121-33. doi:10.1016/j.cell.2006.07.035 10. Unutmaz D. RORC2: the master of human Th17 cell programming. Eur J Immunol . Jun 2009;39(6):1452-5. doi:10.1002/ eji.200939540

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