14781-koppen

159 Water-perfused colonic manometry 7 Spectral analysis In comparison to the adult data, the pediatric data showed very little evidence of cyclic activity of 2–3 cpm prior to or after the meal in either region of the colon (Figure 2). In addition, in contrast to healthy adults, there was no increase in colonic pressure events in the pediatric patient group after the meal. Descending Colon Sigmoid Colon Children Adults Slow transit constipation Health FIGURE 2: Spectral analysis of pressure events in the descending colon (top) and sigmoid colon (bottom), before the meal (A) and after a meal (B), in children (green), adults with slow-transit constipation (red), and healthy adults (blue). The X-axis represents the frequency (cycles per minute) of recorded pressure events, and the Y-axis is the root mean square (RMS) of these pressure spectra (amplitude). The green-, blue-, and red-shaded regions represent the distribution of means over each subject group. The solid green, red, and blue lines in (B; top and bottom) represent the lower edge of the 95% highest density interval of the differences of means between the pre- and postprandial data. Where the solid-colored lines appear above 0 (i.e. above the solid black line in each image), a significant different is observed. In both the descending and sigmoid colon, the green line does not appear above 0 indicating that the meal has no significant effect on the colonic activity in these children. In healthy adults, the solid blue line appears above 0 at all frequencies. Note the pre- and postprandial spike in 2–3 cpm activity in the sigmoid colon of both adult groups. This activity is not evident in the children.