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161 Water-perfused colonic manometry 7 TABLE 2: Characteristics of propagating motor patterns in the descending and sigmoid colon in the children, HA, and adults with STC. Data are shown for 1 hour prior to the meal and the 1 hour from the start of the meal. Preprandial Postprandial Cyclic Short Single Long Single Cyclic Short Single Long Single Antegrade Retrograde Antegrade Retrograde Antegrade Retrograde Antegrade Retrograde Number /1hr Child 2.2 ± 3.5 1.8 ± 2.9 0.7 ± 1.4 1.0 ± 1.9 8 ± 13.3* 5.4 ± 8 3.1 ± 4.7 ( P < 0.0001) 1.8 ± 4.7 0.6 ± 2.0 10.3 ± 15.6 HA 3.5 ± 6.9 3.5 ± 8.5 0.9 ± 2.3 1.9 ± 2.7 0.4 ± 0.9 ( P = 0.005) 10.5 ± 21.6 34.7 ± 45.8 # 0.4 ± 0.6 1.3 ± 2.7 1.5 ± 1.8 STC 2.0 ± 5.4 3.0 ± 5.3 0.3± 1.1 2.1 ± 3.4 0.4 ± 0.7 ( P = 0.003) 2.5 ± 3.7 3.8 ± 5.3 ( P = 0.0006) 0.6 ± 1.0 1.9 ± 2.4 1.8 ± 2.9 Velocity (cm/s) Child 1.2 ± 1.5 0.5 ± 0.3 2.0 ± 1.2 0.4 ± 0.4 2.7 ± 0.7 1.1 ± 1.0 0.6 ± 0.4 2.0 ± 2.4 0.7 ± 0.2 2.9 ± 0.6 HA 1.1 ± 1.3 1.2 ± 1.3 0.5 ± 0.3 0.3 ± 0.1 1.4 ± 1.2 0.8 ± 0.5 0.9 ± 0.4 0.2 ± 0.3 0.5 ± 0.2 1.9 ± 1.0 STC 0.6 ± 0.6 0.4 ± 0.3 0.7 ± 0.6 0.4 ± 0.4 2.0 ± 0.9 0.6 ± 0.5 0.4 ± 0.2 0.5 ± 0.4 0.6 ± 0.4 2.4 ± 0.8 Extent of propagation (cm) Child 5.7 ± 4.5 4.6 ± 3.0 7.6 ± 3.3 3.8 ± 1.8 46.2 ± 5.9 4.9 ± 3.6 4.0 ± 2.8 9.3 ± 5.7 6.3 ± 4.0 47.2 ± 5.9 HA 4.3 ± 1.7 4.9 ± 2.3 5.0 ± 2.6 6.0 ±2.6 43.8 ± 20.3 5.3 ± 2.4 7.3 ± 2.4 5.8 ± 1.3 10.3 ± 2.8 43.2 ± 13.2 STC 2.6 ± 0.9 2.7 ± 0.5 7.9 ± 4.2 4.2 ± 2.0 44.2 ± 5.3 3.9 ± 1.5 4.1 ± 2.5 7.7 ± 7.2 5.4 ± 2.1 54.8 ± 13.0 Amplitude (mmHg) Child 14.5 ± 6.9 19.0 ± 14 15.3 ± 10.3 20.2 ± 14.7 16.2 ± 8.3 20.3 ± 11.0 14.9 ± 4.8 17.3 ± 8.2 12.4 ± 3.2 17.7 ± 8.1 HA 31.5 ± 10.8 43.9 ± 26.1 52.5 ± 32.2 36.6 ± 18.7 49.7 ± 16.5 50.2 ± 15.6 47.3 ± 20.9 79.2 ± 57.2 48.3 ± 16.1 61.9 ± 16.9 STC 49.0 ± 29.6 38.6 ± 14.9 26.1 ± 7.9 33.1 ± 5.9 78.8 ± 80.4 41.8 ± 18.7 39.1 ± 11.5 54.2 ± 23.7 41.3 ± 17.7 75.7 ± 51.7 *Count significantly greater in children than adults (p-values shown in table). †Count significantly greater in healthy adults than children (p-value shown in table). The postprandial count of retrograde cyclic propagating motor patterns has previously been shown to be greater in healthy adults than adult patients with slow-transit constipation. 13 HA, healthy adults; STC, slow-transit constipation.