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164 Chapter 7 Spontaneous and meal-induced HAPS HAPS were identified in one child prior to the meal (no. 12) and in two children after the meal (no. 9 and 12, Table 1). In the child with all the sensors located in the sigmoid colon (no. 12; Table 1), the high-amplitude pressure peaks propagated through the proximal regions of the sigmoid colon and then stopped (Figure 5). This same pattern was observed in this child during the postprandial recording and during bisacodyl infusion (see below & Figure 6). In the other child (no. 9), the postprandial HAPS were observed to extend over the descending and sigmoid colon, terminating at the top of the rectum. As previously reported, 17 these motor patterns were only identified in one adult with slow-transit constipation and in six of the 12 healthy adults. In adults, the HAPS were only recorded in the postprandial phase and not in the preprandial phase. Colonic response to bisacodyl After administration of bisacodyl, HAPS were initiated in 16 of 18 children (Table 1). The first HAPS was recorded 4.3 ± 2.3 min (range, 1.1-7.9 min) after bisacodyl infusion, and there was an average count of 10.1 ± 4.6 (range, 2-19). Defecation occurred after bisacodyl infusion in 14 of 18 children. In two children (no. 4 and 14; Table 1), HAPS were recorded in the absence of defecation, while in another (no. 3, Table 1), defecation occurred without HAPS. An absence of defecation and HAPS was only observed in one child (no. 18; Table 1). FIGURE 5: Spontaneous high-amplitude propagating sequence (HAPS) recorded during prior to the meal in child no. 12 (Table 1). In this child, all of the recording sensors were located in the sigmoid colon. The black oval shapes outline the location of every 2nd sensor. The HAPS terminated at 17 (black circle on the manometry trace). The postprandial HAPS in this child and the bisacodyl induced ones (see Figure 6) all terminated at this same location.