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178 Chapter 8 optic manometry in adults. 13 It is possible that the water that was infused into the colon in children influenced colonic contractility. If this were the case then we would expect to see some differences in colonic motor patterns recorded with a solid state catheter in children with FC. Therefore, in the current study, we aimed to evaluate findings of solid-state colonic manometry in children and adolescents with FC and compare these results with our previously published water-perfused data from children with FC. MATERIALS AND METHODS Study design We performed a retrospective chart review of patients with FC who underwent colonic manometry with a solid-state catheter (36 sensors, 3 cm apart; Unisensor, Switzerland) between September 2013 (the time of introduction of the 36-sensor solid-state colonic manometry catheter at our center) and February 2016. These data were compared with previously published data from children with FC who underwent water-perfused colonic manometry (36 channels, 1.5 cm apart, MMS, Enschede, The Netherlands, stationary manometry version 9.3K). 13 Subjects Children and adolescents were eligible for inclusion if they were 0-21 years of age and had a diagnosis of FC according to the Rome III criteria since childhood. 5 Colonic manometry was generally performed because patients had persistent symptoms of constipation despite their treatment, and were therefore considered to suffer from intractable FC (unresponsive to intensive conventional interventions for ≥3months). 7 Exclusion criteria were: constipation due to known organic causes (e.g., Hirschsprung’s disease, tethered spinal cord, and hypothyroidism) and incomplete data (e.g., as a consequence of a technical problem during the colonic manometry). Admission protocol Patients were admitted to the hospital one day prior to the colonic manometry for a colonic lavage to allow for catheter placement into the colon. In order to improve lavage efficacy, patients also completed a pre-admission home cleanout with high dose polyethylene glycol and stimulant laxatives (bisacodyl or senna). During admission, patients received polyethylene glycol with electrolytes (GoLYTELY®), given via a nasogastric tube. In accordance with regular hospital protocols, polyethylene glycol with electrolytes was administered until the patients passed clear stools. Patients were put on a clear diet 24 hours prior to catheter placement and fasted overnight prior to the catheter placement.