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Part of the research in this thesis was funded by The Royal Netherlands Academy of Arts and Sciences (Academy Ter Meulen Grant) and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (Charlotte Anderson Travel Award). The printing of this thesis was financially supported by: Universiteit van Amsterdam, Nederlandse Vereniging voor Gastroenterologie, Chipsoft, Coloplast B.V., Hero Benelux, Ipsen Farmaceutica B.V., Mead Johnson B.V., Medical Measurement Systems B.V., Norgine B.V., Nutricia Early Life Nutrition, Solgar Vitamins Holland, Teva Nederland B.V., Wellspect HealthCare, Winclove B.V., Yakult Nederland B.V. Layout & cover design: Design Your Thesis | www.designyourthesis.com Printing: Ridderprint B.V. | www.ridderprint.nl ISBN: 978-94-6299-907-7 Copyright © 2018 by Ilan J.N. Koppen. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.