14781-koppen

201 Colonic manometry and contrast enemas 9 FIGURE 2. Inclusion process Comparisons of colonic segment sizecharacteristics betweenchildrenwith fullypropagating HAPCs, prematurely terminating HAPCs and those without HAPCs are shown in Table 3. The SCS ratio differed significantly among the three groups ( P = .026); post-hoc analyses revealed that children with prematurely terminating HAPCs had a significantly larger SCS ratio for colonic diameter compared to children with fully propagating HAPCs and without HAPCs ( P = .008). No significant differences were found between the groups with fully propagating and prematurely terminating HAPCs regarding the number of children with SCS ratios for colonic diameter or length above the 90th percentile or above the mean+2SD as determined in the normative population (data not shown). Regarding the different colonic segments, we compared colonic diameter and length, shown as SCS ratios, with data from a normative pediatric population of children <6 years of age (Table 4, original data are provided in the Supplemental file 1). 21 The SCS ratios for the length of the rectosigmoid and the descending colon were significantly larger in children with FC compared to the normative population ( P < .0001 for both). In the sigmoid colon, the SCS ratio for colonic diameter was significantly larger in children with FC ( P < .0007), but there was no significant difference between the SCS for the diameter of the rectum and the descending colon between the two groups.