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231 Treatment adherence 11 Beliefs about Medication Questionnaire (BMQ) The BMQ assesses beliefs about medication and consists of two parts; the BMQ-Specific and the BMQ-General. 18 The BMQ-Specific comprises two 5-item sections assessing beliefs about the necessity of prescribed medication (e.g. “without my medicines I would be very ill”) and concerns about prescribed medication based on beliefs about the disruptive effects of medication and the danger of dependence and long-term toxicity (e.g. “having to take medicines worries me”). 18 The BMQ-General contains two 4-item sections on medication in general: one pertaining to possible harms that medication could cause (e.g.: “all medicines are poisons”) and one about thoughts on overuse (e.g.“doctors use toomanymedicines”). 18,34 All BMQ questions are scored on a 5-point Likert scale (1 = strongly disagree, 5 = strongly agree) and scores are calculated for all four subscales (Specific-Concerns, Specific-Necessity, General-Harm, General-Overuse). By subtracting the Specific-Concerns score from the Specific-Necessity score, the Necessity-Concerns differential score is obtained, which ranges from -20 to 20 with higher scores indicating stronger perceived necessity and/or lower concerns towards the use of medication. 12 The BMQ has been used in previous pediatric studies on medication adherence. 11,12 Brief Illness Perception Questionnaire (B-IPQ) To assess cognitive and emotional perceptions of illness, the B-IPQ was used. 19 This questionnaire uses a single-item scale approach with 8 questions which are rated on a 10-point Likert scale. Higher scores reflect stronger perceptions of the respective item. Questions pertain to cognitive illness perceptions (identity, cause, timeline, consequences, cure-control), emotional perceptions and overall illness comprehensibility. The ninth and final question of the B-IPQ is an open question on thoughts about the cause of the illness, this item was not included in the analyses in the current study. The B-IPQ has been used in previous studies on adherence in both children and adults. 12,26 Treatment Satisfaction Questionnaire for Medication (TSQM) The TSQM assesses treatment satisfaction and consists of 14 questions, scored on a 7-point Likert scale. 20 The TSQM pertains to four domains: effectiveness, side-effects, convenience, and global satisfaction. Total scores of each domain are converted to score ranging from 0-100, with higher scores indicating higher levels of satisfaction. The TSQM has been used before in studies on adherence in children and adults. 13,35,36 Satisfaction with Information about Medicines Scale (SIMS) The SIMS assesses the extent to which patients feel they have received an adequate amount of information about their medication. 21 The original SIMS questionnaire consists of 17-items, each referring to satisfaction with information about a particular aspect of the medication.

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