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234 Chapter 11 TABLE 1. Patient characteristics Total (n=115) Adherent (n=43) Nonadherent (n=69) P -value a Age in years (median, IQR) 7.8 (4.9-11.3) 6.9 (4.9-10.8) 9.0 (4.8-11.5) .419 Duration of symptoms in months (median, IQR) 42 (24-72) 36 (17-72) 48 (24-72) .251 Sex Female, n (%) Male, n (%) 70 (61) 45 (39) 29 (67) 14 (33) 40 (58) 29 (42) .425 Center of inclusion: Tertiary care center Secondary care center 103 (90) 12 (10) 41 (95) 2 (5) 61 (88) 8 (12) .312 Referral by: General practitioner Pediatrician Pediatric gastroenterologist Missing 70 (61) 36 (31) 8 (7) 1 (1) 31 (72) 9 (21) 3 (7) - 36 (52) 27 (39) 5 (7) 1 (1) .125 Family composition: Parents separated Parents together Missing 20 (17) 88 (77) 7 (6) 8 (19) 34 (79) 1 (2) 10 (15) 54 (78) 5 (7) .792 Siblings: Only child One or more siblings Missing 24 (21) 90 (77) 3 (3) 10 (23) 32 (74) 1 (2) 13 (19) 54 (78) 2 (3) .634 Education level father Low Middle High Missing 18 (16) 42 (37) 51 (44) 4 (4) 5 (12) 14 (33) 23 (54) 1 (2) 12 (17) 27 (39) 28 (41) 2 (3) .434 Education level mother Low Middle High Missing 14 (12) 45 (39) 55 (48) 1 (1) 6 (14) 16 (37) 21 (49) - 8 (12) 26 (38) 34 (49) 1 (1) .963 Use of therapy reminder Pill box Calendar/bowel diary Mobile device app 10 (9) 5 (4) 2 (2) 3 (3) 5 (12) 2 (5) 1 (2) 2 (5) 5 (7) 3 (4) 1 (1) 1 (1) .503 Medication intake Under supervision Autonomous Missing 94 (82) 20 (17) 1 (1) 35 (81) 8 (19) - 56 (81) 12 (17) 1 (1) 1.000 Therapy: Monotherapy PEG Polytherapy: PEG and - Enemas/TAI - MgOx - Bisacodyl - Lactulose 88 (77) 27 (24) 21 (18) 4 (4) 4 (4) 1 (1) 36 (84) 7 (16) 6 (14) 2 (5) - - 49 (71) 20 (29) 15 (22) 2 (3) 4 (6) 1 (1) .173 a Pearson χ 2 . PEG, polyethylene glycol; TAI, transanal irrigation; MgOx, magnesium oxide.

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