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244 Chapter 11 SUPPLEMENTAL FILE 1. Inclusion flowchart. *We were unable to contact 6/25 families who did not return the questionnaire, 19/25 were contacted; 8 reported to have returned the questionnaires via mail but these were never received, 11 agreed to return the questionnaires but these were never received. **6 patients were excluded because they received pharmacological monotherapy other than polyethylene glycol, 5 patients were excluded because they received monotherapy with enemas or transanal rectal irrigation.